1641940-94-4

• 常用中文名：阿尔法骨化醇-D6
• 常用英文名：Alfacalcidol-D6
• CAS号：1641940-94-4
• 分子式：C₂₇H₃₈D₆O₂
• 分子量：406.674
• 相关类别： 信号通路 维生素 D 相关 VD/VDR
• 发布时间：2018-11-09 18:34:43
• 更新时间：2024-01-19 16:37:14
• Alfacalcidol-D6是氘化的Alfacalcidol(1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3),是非选择性的VDR活化剂。

名称

• 中文名: 阿尔法骨化醇-D6
• 英文名: Alfacalcidol-D6
• 英文别名: MFCD22417103

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 531.5±50.0 °C at 760 mmHg
• 分子式: C₂₇H₃₈D₆O₂
• 分子量: 406.674
• 闪点: 222.6±24.7 °C
• 精确质量: 406.371796
• LogP: 8.31
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.534
• 储存条件: 2-8℃

生物活性

• 描述: Alfacalcidol-D6是氘化的Alfacalcidol(1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3),是非选择性的VDR活化剂。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Shiraishi et al (2000) Alfacalcidol inhibits bone resorption and stmulates formation in an ovariectomized rat model of osteoporosis: Distinct actions from estrogen. Journal of Bone and Mineral Research. 15 770.

  [2]. Ringe JD, Schacht E. et al. Prevention and therapy of osteoporosis: the roles of plain vitamin D and alfacalcidol. Rheumatol Int. 2004 Jul;24(4):189-97.

  [3]. Ivarsen P, Povlsen JV, Christensen KL.Effect of alfacalcidol on cardiac function in patients with chronic kidney disease stage 4 and secondary hyperparathyroidism: A pilot study.Scand J Urol Nephrol. 2012 Jun 25.

  [4]. Rianthavorn P,et al. Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone.J Pediatr Endocrinol Metab. 2012;25(3-4):307-12.

  [5]. Ringe JD, Farahmand P, Schacht E.Alfacalcidol in men with osteoporosis: a prospective, observational, 2-year trial on 214 patients.Rheumatol Int. 2012 Apr 8.