地索奈德

• 常用名: 地索奈德
• 英文名: Desonide
• CAS号: 638-94-8
• 分子量: 416.507
• 密度: 1.3±0.1 g/cm3
• 沸点: 580.1±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₂O₆
• 熔点: 274 - 275ºC
• 闪点: 196.9±23.6 °C

地索奈德用途

甾体类皮质激素，治疗内源性湿疹。

地索奈德名称

• 中文名: 地索奈德
• 英文名: desonide

地索奈德生物活性

• 描述: Desonide是非氟化皮质类固醇抗炎剂,能作用于糖皮质激素受体。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Kahanek, N., C. Gelbard, and A. Hebert, Desonide: a review of formulations, efficacy and safety. Expert Opin Investig Drugs, 2008. 17(7): p. 1097-104.

  [2]. Castanedo-Cazares, J.P., et al., Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Clin Cosmet Investig Dermatol, 2013. 6: p. 29-36.

  [3]. Parish, D. and N. Scheinfeld, Desonide foam: a review. Drugs Today (Barc), 2008. 44(1): p. 55-62.

地索奈德物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 580.1±50.0 °C at 760 mmHg
• 熔点: 274 - 275ºC
• 分子式: C₂₄H₃₂O₆
• 分子量: 416.507
• 闪点: 196.9±23.6 °C
• 精确质量: 416.219879
• PSA: 93.06000
• LogP: 2.62
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±3.7 mmHg at 25°C
• 折射率: 1.598
• 储存条件: Refrigerator

地索奈德毒性和生态

地索奈德安全信息

• 危害码 (欧洲): Xn
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2937210000

地索奈德海关

• 海关编码: 2937210000

地索奈德英文别名

• Prednacinolone
• (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• 16a,17a-Isopropylidenedioxyprednisolone
• 2H-naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-
• Desowen
• 2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(2-hydroxyacetyl)-4a,6a,8,8-tetramethyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-
• Locapred
• Desonide
• (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacétyl)-4a,6a,8,8-tétraméthyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodécahydro-2H-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-2-one
• Sterax
• 11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Acetone
• 16a-Hydroxy-D1-hydrocortisone-16a,17a-acetonide
• 16a-Hydroxyprednisolone-16a,17-acetonide
• Steroderm
• 16a-Hydroxyprednisolone Acetonide
• TRIDESILON
• desonidum [INN_la]
• MFCD00866151
• 11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
• (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-Hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-on
• (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-6b-Glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• 11b,21-Dihydroxy-16a,17-isopropylidenedioxy-1,4-pregnadiene-3,20-dione
• Topifug
• d-2083
• EINECS 211-351-6
• 11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
• Budesonide Impurity 6