丰加霉素结构式
|
常用名 | 丰加霉素 | 英文名 | Toyocamycin |
|---|---|---|---|---|
| CAS号 | 606-58-6 | 分子量 | 291.26300 | |
| 密度 | 1.91g/cm3 | 沸点 | 721.1ºC at 760 mmHg | |
| 分子式 | C12H13N5O4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 389.9ºC |
丰加霉素用途Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物,为 X 盒结合蛋白 1 (XBP1) 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂,IC50 值为 80 nM。Toyocamycin (Vengicide) 诱导凋亡,对 IRE1α 的自身磷酸化没有作用。 |
| 中文名 | 4-氨基-5-氰基-7-(beta-d-呋喃核糖)吡咯并[2,3-d]嘧啶 |
|---|---|
| 英文名 | 4-AMINO-5-CYANO-7-(β-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE |
| 英文别名 | 更多 |
| 描述 | Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物,为 X 盒结合蛋白 1 (XBP1) 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂,IC50 值为 80 nM。Toyocamycin (Vengicide) 诱导凋亡,对 IRE1α 的自身磷酸化没有作用。 |
|---|---|
| 相关类别 | |
| 靶点 |
IC50: 80 nM (XBP1 activation)[1] |
| 参考文献 |
| 密度 | 1.91g/cm3 |
|---|---|
| 沸点 | 721.1ºC at 760 mmHg |
| 分子式 | C12H13N5O4 |
| 分子量 | 291.26300 |
| 闪点 | 389.9ºC |
| 精确质量 | 291.09700 |
| PSA | 150.44000 |
| 折射率 | 1.849 |
| 储存条件 | -20°C |
| 危害码 (欧洲) | Xi |
|---|---|
| 危险品运输编码 | NONH for all modes of transport |
| 丰加霉素上游产品 0 | |
|---|---|
| 丰加霉素下游产品 1 | |
|
Synthesis of pyrrolo[2,1-f][1,2,4]triazine C-nucleosides. Isosteres of sangivamycin, tubercidin, and toyocamycin.
Carbohydr. Res. 331(1) , 77-82, (2001) Syntheses of pyrrolo[2,1-f][1,2,4]triazine C-nucleosides are reported. Treatment of pyranulose glycoside with aminoguanidine in acetic acid gave the corresponding semicarbazone in 96% yield. The ring ... |
|
|
Synthesis of 2'-beta-C-methyl toyocamycin and sangivamycin analogues as potential HCV inhibitors.
Bioorg. Med. Chem. Lett. 15(3) , 725-7, (2005) Coupling reaction of 2-beta-C-methyl-1,2,3,4-tetra-O-benzoyl-d-ribofuranose with 4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine, followed by debromination and debenzoylation, gave the 2'-beta-C-methy... |
|
|
Cell cycle arrest and cytochrome c-mediated apoptotic induction in human lung cancer A549 cells by MCS-C2, an analogue of sangivamycin.
J. Microbiol. Biotechnol. 20(2) , 433-7, (2010) In the course of our screening for novel modulators on cell cycle progression and apoptosis as anticancer drug candidates, we generated an analogue of sangivamycin, MCS-C2, designated as 4-amino-6-bro... |
| TOYOCAMYCIN |
| vengicide |
| siromycin |
| a-399-y4 |
| unamycin-b |
| e-212 |
| uramycinb |
| 7-Cyano-7-deazaadenosine |
| e-212-1 |
查看所有供应商和价格请点击：
![5-chloro-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene-7-carbonitrile结构式](https://www.chemsrc.com/caspic/495/52443-16-0.png)
CAS号52443-16-0