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606-58-6生产厂家

606-58-6价格

606-58-6

606-58-6结构式
606-58-6结构式
  • 常用中文名:丰加霉素
  • 常用英文名:Toyocamycin
  • CAS号:606-58-6
  • 分子式:C12H13N5O4
  • 分子量:291.26300
  • 相关类别: 信号通路 细胞周期/DNA损伤 IRE1
  • 发布时间:2019-01-10 17:31:49
  • 更新时间:2024-01-11 07:25:18
  • Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物,为 X 盒结合蛋白 1 (XBP1) 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂,IC50 值为 80 nM。Toyocamycin (Vengicide) 诱导凋亡,对 IRE1α 的自身磷酸化没有作用。

化源商城直购

中文名 4-氨基-5-氰基-7-(beta-d-呋喃核糖)吡咯并[2,3-d]嘧啶
英文名 4-AMINO-5-CYANO-7-(β-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE
英文别名 TOYOCAMYCIN
vengicide
siromycin
a-399-y4
unamycin-b
e-212
uramycinb
7-Cyano-7-deazaadenosine
e-212-1
描述 Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物,为 X 盒结合蛋白 1 (XBP1) 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂,IC50 值为 80 nM。Toyocamycin (Vengicide) 诱导凋亡,对 IRE1α 的自身磷酸化没有作用。
相关类别
靶点

IC50: 80 nM (XBP1 activation)[1]

参考文献

[1]. Toyocamycin, et al. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J. 2012 Jul;2(7):e79.

密度 1.91g/cm3
沸点 721.1ºC at 760 mmHg
分子式 C12H13N5O4
分子量 291.26300
闪点 389.9ºC
精确质量 291.09700
PSA 150.44000
折射率 1.849
储存条件 -20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY9100000
CHEMICAL NAME :
7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER :
606-58-6
BEILSTEIN REFERENCE NO. :
0048454
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C12-H13-N5-O4
MOLECULAR WEIGHT :
291.30
WISWESSER LINE NOTATION :
T56 BN GN INJ DCN FZ B- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
71 ug/L
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,481,1987

危害码 (欧洲) Xi
危险品运输编码 NONH for all modes of transport
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