URB-597

更新时间:2024-01-02 20:51:47

URB-597结构式
URB-597结构式
品牌特惠专场
常用名 URB-597 英文名 URB597
CAS号 546141-08-6 分子量 338.400
密度 1.2±0.1 g/cm3 沸点 533.2±50.0 °C at 760 mmHg
分子式 C20H22N2O3 熔点 N/A
MSDS 中文版 美版 闪点 276.3±30.1 °C
符号 GHS07 GHS09
GHS07, GHS09
信号词 Warning

 URB-597用途


URB597是口服生物相容性的FAAH抑制剂,IC50为4.6 nM,对其它的cannabinoid-相关靶点无活性。

 URB-597名称

中文名 3'-氨基甲酰-[1,1'-联苯]-3-基环己基氨基甲酸酯
英文名 3'-Carbamoyl-[1,1'-biphenyl]-3-yl cyclohexylcarbamate
中文别名 东凌草素 | 3'-胺甲酰基联苯-3-基环己基氨基甲酸甲酯 | 3'-胺甲酰基联苯-3-基环己基氨基甲酸酯 | N-环己基氨基甲酸 3'-(氨基甲酰基)[1,1'-联苯]-3-基酯
英文别名 更多

 URB-597物理化学性质

密度 1.2±0.1 g/cm3
沸点 533.2±50.0 °C at 760 mmHg
分子式 C20H22N2O3
分子量 338.400
闪点 276.3±30.1 °C
精确质量 338.163055
PSA 81.42000
LogP 3.51
外观性状 powder | white
蒸汽压 0.0±1.4 mmHg at 25°C
折射率 1.618
储存条件 2-8°C
水溶解性 DMSO: ~14 mg/mL, soluble

 URB-597MSDS

 URB-597安全信息

符号 GHS07 GHS09
GHS07, GHS09
信号词 Warning
危害声明 H319-H410
警示性声明 P273-P305 + P351 + P338-P501
个人防护装备 Eyeshields;Gloves
危害码 (欧洲) N
风险声明 (欧洲) 50/53
安全声明 (欧洲) 22-24/25-60-61
危险品运输编码 UN 3077 9/PG 3
WGK德国 3
海关编码 2924299090

 URB-597海关

海关编码 2924299090
中文概述 2924299090. 其他环酰胺(包括环氨基甲酸酯)(包括其衍生物以及他们的盐). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 包装
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 URB-597文献39

更多文献
Activation of PPAR gamma receptors reduces levodopa-induced dyskinesias in 6-OHDA-lesioned rats.

Neurobiol. Dis. 74 , 295-304, (2015)

Long-term administration of l-3,4-dihydroxyphenylalanine (levodopa), the mainstay treatment for Parkinson's disease (PD), is accompanied by fluctuations in its duration of action and motor complicatio...

Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies.

Neurobiol. Dis. 79 , 41-50, (2015)

Anandamide (AEA) is an endocannabinoid (EC) that modulates multiple functions in the CNS and that is released in areas of injury, exerting putative neuroprotective actions. In the present study, we ha...

Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent.

Biochem. Pharmacol. 92(4) , 669-89, (2014)

Besides the suggested role of a putative endocannabinoid membrane transporter mediating the cellular uptake of the endocannabinoid anandamide (AEA), this process is intrinsically coupled to AEA degrad...

 URB-597英文别名

cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester
URB597
3'-Carbamoyl-3-biphenylyl cyclohexylcarbamate
Carbamic acid, N-cyclohexyl-, 3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester
3'-Carbamoylbiphenyl-3-yl cyclohexylcarbamate
Cyclohexyl-carbamic acid 3'-carbamoyl-biphenyl-3-yl ester
[3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate
3'-(aminocarbonyl)-1,1'-biphenyl-3-yl cyclohexylcarbamate
URB-597
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