异落新妇苷

• 常用名: 异落新妇苷
• 英文名: Isoastilbin
• CAS号: 54081-48-0
• 分子量: 450.393
• 密度: 1.7±0.1 g/cm3
• 沸点: 801.1±65.0 °C at 760 mmHg
• 分子式: C₂₁H₂₂O₁₁
• 熔点: N/A
• 闪点: 282.9±27.8 °C

异落新妇苷用途

Isoastilbin,Rhizoma Smilacis glabrae 和 Astragalus membranaceus 中的一种二氢黄酮醇糖苷化合物。Isoastilbin 抑制葡萄糖基转移酶 (GTase) 的 IC50 值为 54.3 μg/mL,还抑制酪氨酸酶 (tyrosinase) 活性。Isoastilbin 具有神经保护,抗氧化,抗微生物和抗凋亡的特性,并可用于阿尔茨海默氏病的研究。

异落新妇苷名称

• 中文名: 异落新妇苷
• 英文名: (2R,3S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihydro-2 H-chromen-3-yl 6-deoxy-α-L-mannopyranoside

异落新妇苷生物活性

• 描述: Isoastilbin,Rhizoma Smilacis glabrae 和 Astragalus membranaceus 中的一种二氢黄酮醇糖苷化合物。Isoastilbin 抑制葡萄糖基转移酶 (GTase) 的 IC50 值为 54.3 μg/mL,还抑制酪氨酸酶 (tyrosinase) 活性。Isoastilbin 具有神经保护,抗氧化,抗微生物和抗凋亡的特性,并可用于阿尔茨海默氏病的研究。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 代谢酶/蛋白酶 >> 酪氨酸酶
  研究领域 >> 神经疾病
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  IC50: 54.3 μg/mL (Glucosyltransferase (GTase)[2]

• 参考文献:

  [1]. Hong Yu, et al. Protective Roles of Isoastilbin Against Alz heimer's Disease via Nrf2-mediated Antioxidation and anti‑apoptosis. Int J Mol Med. 2019 Mar;43(3):1406-1416.

  [2]. Harlinda Kuspradini, et al. Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extracts. J. Wood Sci., 2009, 55(4):308-13.

  [3]. Batubara, Irmanida, et al. Anti-acne and Tyrosinase Inhibition Properties of Taxifolin and Some Flavanonol Rhamnosides from Kempas. Wood Research Journal ,2010, 1(1):45-9.

异落新妇苷物理化学性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 801.1±65.0 °C at 760 mmHg
• 分子式: C₂₁H₂₂O₁₁
• 分子量: 450.393
• 闪点: 282.9±27.8 °C
• 精确质量: 450.116211
• PSA: 186.37000
• LogP: 2.97
• 外观性状: 粉末
• 蒸汽压: 0.0±3.0 mmHg at 25°C
• 折射率: 1.748
• 储存条件: 2-8℃，干燥，密闭，避光

异落新妇苷安全信息

• 危害码 (欧洲): Xi

异落新妇苷英文别名

• 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-, (2R,3R)-
• Astilbin Dihydroquercetin 3-rhamnoside Taxifolin 3-rhamnoside
• 4H-1-Benzopyran-4-one, 3-((6-deoxy-α-L-mannopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-, (2R,3R)-
• Taxifolin 3-rhamnoside
• Neoisoastilbin
• Astilbin
• (2R-trans)-3-((6-Deoxy-α-L-mannopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one
• 4H-1-Benzopyran-4-one, 3-((6-deoxy-α-L-mannopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-, (2R-trans)-
• Taxifolin 3-O-rhamnoside
• Astilbin from Engelhardtia roxburghiana
• (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3-dihydrochromen-4-one
• (2R,3R)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-chromen-3-yl 6-deoxy-α-L-mannopyranoside
• Isoastilbin