(S)-SNAP5114

更新时间：2024-01-10 06:54:05

(S)-SNAP5114结构式	常用名	(S)-SNAP5114	英文名	(S)-SNAP 5114
	CAS号	157604-55-2	分子量	505.60
	密度	1.175g/cm3	沸点	643.9ºC at 760mmHg
	分子式	C₃₀H₃₅NO₆	熔点	N/A
	MSDS	中文版美版	闪点	343.2ºC
	符号	GHS07	信号词	Warning

(S)-SNAP5114用途

(S)-SNAP5114 是一个选择性的 GABA 转运的抑制剂,其对hGAT-3和rGAT-2的 IC50 值分别为5 μM 和21 μM。 (S)-SNAP5114 是一种抗惊厥药。

中文名	(S)-SNAP5114
英文名	(3S)-1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid
英文别名	更多

描述	(S)-SNAP5114 是一个选择性的 GABA 转运的抑制剂,其对hGAT-3和rGAT-2的 IC50 值分别为5 μM 和21 μM。 (S)-SNAP5114 是一种抗惊厥药。
相关类别	信号通路 >> 跨膜转运 >> GABA受体研究领域 >> 神经疾病信号通路 >> 神经信号通路 >> GABA受体
靶点	IC50: 5 μM (hGAT-3), 21 μM (rGAT-2)[1].
参考文献	[1]. Borden LA, et al. Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels. 1994;2(3):207-13. [2]. Borden LA, et al. GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem Int. 1996 Oct;29(4):335-56.

密度	1.175g/cm3
沸点	643.9ºC at 760mmHg
分子式	C₃₀H₃₅NO₆
分子量	505.60
闪点	343.2ºC
精确质量	505.24600
PSA	77.46000
LogP	4.75540
蒸汽压	0mmHg at 25°C
折射率	1.571
储存条件	-20°C

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P261-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xi: Irritant;
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	S26
危险品运输编码	NONH for all modes of transport

GABA transporter heterogeneity: pharmacology and cellular localization.

Neurochem. Int. 29 , 335, (1996)

gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. GABA is cleared from the synaptic cleft by specific, high-affinity, sodium- and chloride-dependent trans...

GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.

Neuropharmacology 39 , 2399-2407, (2000)

The present study examines the effect of tiagabine (a selective inhibitor of GABA transporter 1, GAT-1), SNAP-5114 (a semi-selective inhibitor of rat GAT-3/mouse GAT4) and NNC 05-2045 (a non-selective...

GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii.

PLoS Pathog. 8 , e1003051, (2012)

During acute infection in human and animal hosts, the obligate intracellular protozoan Toxoplasma gondii infects a variety of cell types, including leukocytes. Poised to respond to invading pathogens,...

HMS3268E15

SNAP-5114

Pseudo RACK1

(S)-SNAP-5114