(S)-SNAP 5114

Modify Date: 2024-01-10 06:54:05

(S)-SNAP 5114 structure	Common Name	(S)-SNAP 5114
	CAS Number	157604-55-2	Molecular Weight	505.60
	Density	1.175g/cm3	Boiling Point	643.9ºC at 760mmHg
	Molecular Formula	C₃₀H₃₅NO₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	343.2ºC
	Symbol	GHS07	Signal Word	Warning

Use of (S)-SNAP 5114

(S)-SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant drug[1][2].

Name	(3S)-1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid
Synonym	More Synonyms

Description	(S)-SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant drug[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	IC50: 5 μM (hGAT-3), 21 μM (rGAT-2)[1].
References	[1]. Borden LA, et al. Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels. 1994;2(3):207-13. [2]. Borden LA, et al. GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem Int. 1996 Oct;29(4):335-56.

Density	1.175g/cm3
Boiling Point	643.9ºC at 760mmHg
Molecular Formula	C₃₀H₃₅NO₆
Molecular Weight	505.60
Flash Point	343.2ºC
Exact Mass	505.24600
PSA	77.46000
LogP	4.75540
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.571
Storage condition	-20°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport

GABA transporter heterogeneity: pharmacology and cellular localization.

Neurochem. Int. 29 , 335, (1996)

gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. GABA is cleared from the synaptic cleft by specific, high-affinity, sodium- and chloride-dependent trans...

GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.

Neuropharmacology 39 , 2399-2407, (2000)

The present study examines the effect of tiagabine (a selective inhibitor of GABA transporter 1, GAT-1), SNAP-5114 (a semi-selective inhibitor of rat GAT-3/mouse GAT4) and NNC 05-2045 (a non-selective...

GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii.

PLoS Pathog. 8 , e1003051, (2012)

During acute infection in human and animal hosts, the obligate intracellular protozoan Toxoplasma gondii infects a variety of cell types, including leukocytes. Poised to respond to invading pathogens,...

HMS3268E15

SNAP-5114

Pseudo RACK1

(S)-SNAP-5114

DC Chemicals Limited
China
Product Name: SNAP 5114
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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(S)-SNAP 5114

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