GR-73632

更新时间：2024-04-05 18:07:49

GR-73632结构式	常用名	GR-73632	英文名	GR 73632
	CAS号	133156-06-6	分子量	766.00500
	密度	1.198g/cm3	沸点	1082.2ºC at 760mmHg
	分子式	C₄₀H₅₉N₇O₆S	熔点	N/A
	MSDS	美版	闪点	608.3ºC

GR-73632用途

GR-73632 是新型速激肽神经激肽1 (NK-1) 受体激动剂。GR-73632 通过传递瘙痒信号的 NK1 受体直接作用于初级感觉神经元的外周末端。

英文名	(2S)-N-[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-1-[(2S)-2-[[(2S)-2-(5-aminopentanoylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]-N-methylpyrrolidine-2-carboxamide
英文别名	更多

描述	GR-73632 是新型速激肽神经激肽1 (NK-1) 受体激动剂。GR-73632 通过传递瘙痒信号的 NK1 受体直接作用于初级感觉神经元的外周末端。
相关类别	信号通路 >> 神经信号通路 >> 神经激肽受体研究领域 >> 神经疾病信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体
靶点	IC50: NK-1 receptor[1]
参考文献	[1]. Sakurada C, et al. Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides. 1999;20(2):301-4. [2]. Costantini VJ, et al. The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration. Exp Dermatol. 2015 Apr;24(4):312-4.

密度	1.198g/cm3
沸点	1082.2ºC at 760mmHg
分子式	C₄₀H₅₉N₇O₆S
分子量	766.00500
闪点	608.3ºC
精确质量	765.42500
PSA	222.33000
LogP	4.66890
蒸汽压	0mmHg at 25°C
折射率	1.576
储存条件	-20°C，密封，干燥

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
安全声明 (欧洲)	S22
危险品运输编码	NONH for all modes of transport

Neurokinin receptor modulation of respiratory activity in the rabbit.

Eur. J. Neurosci. 27(12) , 3233-43, (2008)

The respiratory role of neurokinin (NK) receptors was investigated in alpha-chloralose-urethane-anaesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinject...

Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons.

Neuropharmacology 55(8) , 1405-11, (2008)

The present study was conducted to determine whether the activation of neurokinin-1 receptor (NK-1R) by its agonist (GR73632) enhances the capsaicin-evoked substance P (SP) release using a radioimmuno...

Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.

Clin. Cancer Res. 12(13) , 4112-8, (2006)

Intestinal toxicity is important in the therapeutic use of radiation as well as in nontherapeutic radiation exposure scenarios. Enteric sensory nerves are critical for mucosal homeostasis and for an a...

GR-73632