Zolantidine dimaleate

更新时间：2024-01-07 12:37:49

Zolantidine dimaleate结构式	常用名	Zolantidine dimaleate	英文名	Zolantidine dimaleate
	CAS号	104076-39-3	分子量	613.68
	密度	N/A	沸点	N/A
	分子式	C₃₀H₃₅N₃O₉S	熔点	N/A
	MSDS	美版	闪点	N/A

Zolantidine dimaleate用途

二马来酸唑安定(SKF 95282二马来酸)是一种强效、选择性和跨血脑屏障组胺H2拮抗剂。二马来酸左安定诱导镇痛感受[1][2]。

英文名	AL1YII70LM
英文别名	更多

描述	二马来酸唑安定(SKF 95282二马来酸)是一种强效、选择性和跨血脑屏障组胺H2拮抗剂。二马来酸左安定诱导镇痛感受[1][2]。
相关类别	信号通路 >> 免疫及炎症 >> 组胺受体研究领域 >> 神经疾病信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
靶点	H2 Receptor
体内研究	二马来酸左安定(5、10、20、40mg/kg皮下注射) 在胆汁淤积大鼠中诱导抗伤害作用[2] 动物模型：200-250g,雄性Wistar大鼠(胆汁淤积大鼠)[2]剂量：5、10、20、40mg/kg给药：S.c.结果：甩尾潜伏期显著增加,并诱导镇痛感受。
参考文献	[1]. Calcutt CR, et al. Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist. Br J Pharmacol. 1988 Jan;93(1):69-78. [2]. Hasanein P. Two histamine H2 receptor antagonists, zolantidine and cimetidine, modulate nociception in cholestatic rats. J Psychopharmacol. 2011 Feb;25(2):281-8.

分子式	C₃₀H₃₅N₃O₉S
分子量	613.68
精确质量	613.209412

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist.

Br. J. Pharmacol. 93(1) , 69-78, (1988)

1. The novel benzthiazole derivative zolantidine (SK&F 95282) is a potent antagonist of histamine at H2-receptors in guinea-pig atrium and rat uterus. Only apparent pA2 values of 7.46 and 7.26 respect...

Linking solubility and permeability assays for maximum throughput and reproducibility.

J. Biomol. Screen. 10(4) , 383-90, (2005)

Solubility and permeability are intimately linked in drug absorption processes. They have, however, been traditionally assayed separately. To support this linkage, a combined solubility/permeability a...

Identification of novel functional inhibitors of acid sphingomyelinase.

PLoS ONE 6 , e23852, (2011)

We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional Inhibitors of Acid Sphing...

2-Benzothiazolamine, N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-, (2Z)-2-butenedioate (1:2)

AL1YII70LM

Zolantidine dimaleate

N-{3-[3-(Piperidin-1-ylmethyl)phenoxy]propyl}-1,3-benzothiazol-2-amine (2Z)-but-2-enedioate (1:2)

N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]-2-benzothiazolamine dimaleate

SKF 95282 dimaleate

SKF-95282 dimaleate salt

N-{3-[3-(1-Piperidinylmethyl)phenoxy]propyl}-1,3-benzothiazol-2-amine (2Z)-2-butenedioate (1:2)