10402-53-6

• 常用中文名：盐酸依普拉酮
• 常用英文名：Eprazinone 2HCl
• CAS号：10402-53-6
• 分子式：C₂₄H₃₄Cl₂N₂O₂
• 分子量：453.445
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 神经激肽受体
• 发布时间：2018-02-21 08:00:00
• 更新时间：2024-01-03 14:57:37
• Eprazinone dihydrochloride 是一种具有粘液溶解,分泌分解,镇咳和支气管解痉性质的药物。Eprazinone dihydrochloride 是一种神经激肽 1 受体 (NK1R) 的配体。Eprazinone dihydrochloride 可用于慢性支气管炎的研究,可改善肺功能和动脉血氧分压。

名称

• 中文名: 盐酸依普拉酮
• 英文名: eprazinone hydrochloride
• 中文别名: 氯化胆硷; 1-(2-苯甲酰丙基)-4-(2-乙氧基-2-苯基乙基)哌嗪二盐酸盐
• 英文别名: 3-[4-(2-Ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-1-propanone, dihydrochloride; 3-[4-(2-Ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-1-propanone dihydrochloride; 3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-one dihydrochloride; 3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-one,dihydrochloride; 3-(4-(2-Ethoxy-2-phenylethyl)piperazin-1-yl)-2-methyl-1-phenylpropan-1-one dihydrochloride; UNII:394X1L8I9Y; Eprazinone dihydrochloride; 1-Propanone, 3-[4-(2-ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-, hydrochloride (1:2); eprazinone di-hcl

物化性质

• 密度: 1.064 g/cm3
• 沸点: 503.9ºC at 760 mmHg
• 分子式: C₂₄H₃₄Cl₂N₂O₂
• 分子量: 453.445
• 闪点: 258.5ºC
• 精确质量: 452.199738
• PSA: 32.78000
• LogP: 5.38060
• 外观性状: 一种白色或近乎于白色晶体
• 蒸汽压: 2.8E-10mmHg at 25°C
• 储存条件: 2~8℃

生物活性

• 描述: Eprazinone dihydrochloride 是一种具有粘液溶解,分泌分解,镇咳和支气管解痉性质的药物。Eprazinone dihydrochloride 是一种神经激肽 1 受体 (NK1R) 的配体。Eprazinone dihydrochloride 可用于慢性支气管炎的研究,可改善肺功能和动脉血氧分压。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 神经信号通路 >> 神经激肽受体
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体
• 靶点:

  Neurokinin 1 receptor[1]

• 体外研究: 尽管在25μM浓度下,依丙嗪酮对[125I]BH-SP与NK1R的结合表现出相当弱的抑制作用,且拮抗作用约为30%,但NK1R阻断可促进其粘溶活性[2]。
• 体内研究: 200 mg/kg剂量的Eprazinone(50-200 mg/kg；经口灌胃；每日；连续4天；成年雄性大鼠)显著增加总磷脂和单个磷脂(磷脂酰肌醇除外)水平,降低总中性脂质。低剂量的Eprazinone显著降低中性脂质水平而不影响磷脂[1]。在气道上皮研究中,粘膜加入Eprazinone可引起剂量依赖性的部分可逆性短路电流(Isc)降低。在较低浓度的依丙嗪酮下,Isc的减少完全是由于净氯化物分泌的减少,而在较高浓度下,钠和氯化物的运输都受到影响[1]。动物模型：成年雄性无病原体Fischer 344近交系大鼠(200-250 g)[1]剂量：50 mg/kg、100 mg/kg和200 mg/kg给药：口服灌胃；每日；连续4天结果：200 mg/kg给药可显著提高总和个体(磷脂酰肌醇除外)磷脂水平,降低总中性脂质。
• 参考文献:

  [1]. R S Thrall, et al. Eprazinone Alters Lung Lavage Lipid Levels and Transtracheal Ion Transport. Exp Lung Res. May-Jun 1992;18(3):409-20.

  [2]. Yvonne Krautscheid, et al. Pharmacophore Modeling, Virtual Screening, and in Vitro Testing Reveal Haloperidol, Eprazinone, and Fenbutrazate as Neurokinin Receptors Ligands. J Chem Inf Model. 2014 Jun 23;54(6):1747-57.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Eprazinone diHCl Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Eprazinone diHCl CAS number:10402-53-6 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C24H34Cl2N2O2 Molecular weight:453.4 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UH1599500 CHEMICAL NAME : Propiophenone, 2-(4-(beta-ethoxyphenethyl)-1-piperazinyl)methyl-, dihydrochloride CAS REGISTRY NUMBER : 10402-53-6 LAST UPDATED : 199503 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C24-H32-N2-O2.2Cl-H MOLECULAR WEIGHT : 453.50 WISWESSER LINE NOTATION : T6N DNTJ A1Y1&VR& D1YR&O2 &GH 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 763 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 10,232,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 191 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 10,232,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 238 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 10,232,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 286 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 10,232,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 116 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCIPDV Beijing Yixueyuan Xuebao. Journal of Peking Medical College. (Beijing Yixueyuan, Beijiaohaidianqu, Beijing, Peop. Rep. China) 19??-V.17(3), 1985. Volume(issue)/page/year: 13(2),98,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,314,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCIPDV Beijing Yixueyuan Xuebao. Journal of Peking Medical College. (Beijing Yixueyuan, Beijiaohaidianqu, Beijing, Peop. Rep. China) 19??-V.17(3), 1985. Volume(issue)/page/year: 13(2),98,1981

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%