左羟丙哌嗪
左羟丙哌嗪用途
左羟丙哌嗪名称
[ CAS 号 ]:
99291-25-5
[ 中文名 ]:
左羟丙哌嗪
[ 英文名 ]:
Levodropropizine
[中文别名 ]:
[英文别名 ]:
- (S)-dropropizine
- Levdropropizina
- 1,2-Propanediol,3-(4-phenyl-1-piperazinyl)-,(R)
- (-)-Dropropizine
- rapitux
- (+)-Dropropizine
- (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol
- (R)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol
- Levdropropizina [Latin,Spanish]
- (2S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
左羟丙哌嗪生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
左羟丙哌嗪物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
412.7±34.0 °C at 760 mmHg
[ 熔点 ]:
102-106ºC
[ 分子式 ]:
C13H20N2O2
[ 分子量 ]:
236.310
[ 闪点 ]:
220.9±24.3 °C
[ 精确质量 ]:
236.152481
[ PSA ]:
46.94000
[ LogP ]:
0.46
[ 外观性状 ]:
白色晶体粉末
[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C
[ 折射率 ]:
1.577
[ 储存条件 ]:
Refrigerator
左羟丙哌嗪毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TZ1075100
- CHEMICAL NAME :
- 1,2-Propanediol, 3-(4-phenylpiperazin-1-yl)-, S(-)-
- CAS REGISTRY NUMBER :
- 99291-25-5
- LAST UPDATED :
- 199609
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C13-H20-N2-O2
- MOLECULAR WEIGHT :
- 236.35
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 887 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 401 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1281 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 408 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2493 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - other changes
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988
左羟丙哌嗪安全信息
[ 海关编码 ]:
2933599090
左羟丙哌嗪合成路线
左羟丙哌嗪上下游产品
左羟丙哌嗪上游产品
左羟丙哌嗪下游产品
左羟丙哌嗪海关
[ 海关编码 ]: 2933599090
[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
左羟丙哌嗪文献
J. Int. Med. Res. 23(3) , 175-83, (1995)
The antitussive efficacy and tolerability of dropropizine and of its enantiomer levodropropizine were evaluated in children with non-productive cough; 258 were evaluable for tolerability and 254 for e...
Efficacy of levodropropizine in pediatric cough.Pulm. Pharmacol. Ther. 25(5) , 337-42, (2012)
Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respir...
Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.Ther. Drug Monit. 26(4) , 441-9, (2004)
Studies are described on the metabolism and the toxicologic analysis of the nonopioid cough suppressant dropropizine [R,S-3-(4-phenyl-1-piperazinyl)1,2-propandiol, DRO] in human urine using gas chroma...
推荐生产厂家/供应商:
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:Levodropropizine
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥949.0/100mg
¥709.0/50mg
¥需询单/1g
¥需询单/1g
联系人:李先生
产品详情:Levodropropizine
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥128.0/5g
¥421.0/25g
¥1247.0/100g
¥940.8/100mg
联系人:夏言
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥39.9/1g
¥449.9/25g
¥129.9/5g
¥1259.9/100g
联系人:阿拉丁李高志
产品详情:左羟丙哌嗪
公司名:上海陌孚医药科技有限公司
区域:上海市嘉定区
价格:
¥635.04/50mg
¥846.72/100mg
联系人:朱经理
产品详情:Levodropropizine
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相关化合物
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