99291-25-5

• 常用中文名：左羟丙哌嗪
• 常用英文名：Levodropropizine
• CAS号：99291-25-5
• 分子式：C₁₃H₂₀N₂O₂
• 分子量：236.310
• 相关类别： 医药中间体 杂环化合物 哌嗪类化合物
• 发布时间：2018-02-21 08:00:00
• 更新时间：2025-08-21 12:29:58
• Levodropropizine (DF-526) 是组胺受体抑制剂。Levodropropizine (DF-526) 是一种有效的, 良好耐受性的镇咳药。

名称

• 中文名: 左羟丙哌嗪
• 英文名: levodropropizine
• 中文别名: (S)-3-(4-苯基-1-哌嗪基)-1,2-丙二醇
• 英文别名: (S)-dropropizine; Levdropropizina; 1,2-Propanediol,3-(4-phenyl-1-piperazinyl)-,(R); (-)-Dropropizine; rapitux; 1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-, (2S)-; (+)-Dropropizine; (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol; (R)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol; Levdropropizina [Latin,Spanish]; (2S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol; (R)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol; Levodropropizine; Dropropizine S-form

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 412.7±34.0 °C at 760 mmHg
• 熔点: 102-106ºC
• 分子式: C₁₃H₂₀N₂O₂
• 分子量: 236.310
• 闪点: 220.9±24.3 °C
• 精确质量: 236.152481
• PSA: 46.94000
• LogP: 0.46
• 外观性状: 白色晶体粉末
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.577
• 储存条件: Refrigerator

生物活性

• 描述: Levodropropizine (DF-526) 是组胺受体抑制剂。Levodropropizine (DF-526) 是一种有效的, 良好耐受性的镇咳药。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Zanasi A, et al. Levodropropizine for treating cough in adult and children: a meta-analysis of published studies. Multidiscip Respir Med. 2015 May 31;10(1):19.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TZ1075100 CHEMICAL NAME : 1,2-Propanediol, 3-(4-phenylpiperazin-1-yl)-, S(-)- CAS REGISTRY NUMBER : 99291-25-5 LAST UPDATED : 199609 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C13-H20-N2-O2 MOLECULAR WEIGHT : 236.35 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 887 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 401 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1281 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 408 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 2493 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988

安全

• 海关编码: 2933599090

合成路线

92-54-6 ~% 99291-25-5

文献：US4699911 A1, ;

92-54-6 50765-70-3 ~47% 99291-25-5

文献：Giani; Marinone; Melillo; Borsa; Tonon Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 8 p. 1139 - 1141

92-54-6 70987-78-9 ~% 99291-25-5

文献：Arzneimittel-Forschung/Drug Research, , vol. 38, # 8 p. 1139 - 1141

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海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%