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7-氨基头孢烷酸

7-氨基头孢烷酸用途

7-Aminocephalosporanic acid是合成头孢菌素类抗生素的核心化学结构, 是有效的β-lactamase抑制剂。

7-氨基头孢烷酸名称

[ CAS 号 ]:
957-68-6

[ 中文名 ]:
7-氨基头孢烷酸

[ 英文名 ]:
7-Aminocephalosporanic acid

[中文别名 ]:

[英文别名 ]:

7-ACS
(7R)-7-Aminocephalosporanic acid
EINECS 213-485-0
7-AMINO CEPHALOSPORIC ACID
7beta-aminocephalosporanic acid
7β-aminocephalosporanic acid zwitterion
3-Acetoxymethyl-7-aminoceph-3-em-4-oic Acid
7β-aminocephalosporanic acid
7-Amino
MFCD00005177

7-氨基头孢烷酸生物活性

[ 描述 ]:

7-Aminocephalosporanic acid是合成头孢菌素类抗生素的核心化学结构, 是有效的β-lactamase抑制剂。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

7-氨基头孢烷酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
560.6±50.0 °C at 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₁₀H₁₂N₂O₅S

[ 分子量 ]:
272.278

[ 闪点 ]:
292.9±30.1 °C

[ 精确质量 ]:
272.046692

[ PSA ]:
135.23000

[ LogP ]:
-0.80

[ 外观性状 ]:
固体;White to Light yellow to Light orange powder to crystal

[ 蒸汽压 ]:
0.0±3.3 mmHg at 25°C

[ 折射率 ]:
1.661

[ 储存条件 ]:
2-8°C

7-氨基头孢烷酸MSDS

详细MSDS(安全技术说明书)

7-氨基头孢烷酸安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn,Xi

[ 风险声明 (欧洲) ]:
R42/43:May cause sensitization by inhalation and skin contact . R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .

[ 安全声明 (欧洲) ]:
S22-S36/37-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934996000

7-氨基头孢烷酸合成路线

详细合成路线

7-氨基头孢烷酸上下游产品

7-氨基头孢烷酸上游产品

7-氨基头孢烷酸下游产品

7-氨基头孢烷酸制备

从半合成头孢菌素的基本原料——头孢菌素C出发，用三甲基氯硅烷酯化，再经五氯化磷氯化、丁醇醚化，最后水解而得。从头孢菌素C钠到7-ACA的收率约50%。

7-氨基头孢烷酸海关

[ 海关编码 ]: 2934996000

[ 中文概述 ]:
2934996000. 7-苯乙酰氨基-3-氯甲基-4-头孢烷酸对甲氧基苄酯、7-氨基头孢烷酸、7-氨基脱乙酰氧基头孢烷酸. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最低关税:6.0%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934996000. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:6.0%. General tariff:20.0%

7-氨基头孢烷酸文献

Construction of recombinant Escherichia coli D11/pMSTO and its use in enzymatic preparation of 7-aminocephalosporanic acid in one pot.

J. Biotechnol. 129(3) , 400-5, (2007)

The main drawback in the industrial production of 7-aminocephalosporanic acid is the accumulation of intermediate (AKA-7-ACA) and destruction of substrate (cephalosporin C) catalyzed by catalase and b...

Batch production of deacetyl 7-aminocephalosporanic acid by immobilized cephalosporin-C deacetylase.

Appl. Microbiol. Biotechnol. 65(3) , 263-7, (2004)

Bacillus subtilis SHS0133 cephalosporin-C deacetylase (CAH) overexpressed in Escherichia coli was immobilized on an anion-exchange resin, KA-890, using glutaraldehyde. The activity yield of immobilize...

Site-specific protonation microequilibria of penicillin and cephalosporin beta-lactam core molecules.

Eur. J. Pharm. Sci. 32(1) , 1-7, (2007)

Acid-base chemistry of 6-aminopenicillanic acid (6-APA) and 7-aminocephalosporanic acid (7-ACA), the fundamental units of the two classical antibiotic families is characterised at the macroscopic and ...

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