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7-氨基去乙酰氧基头孢烷酸

7-氨基去乙酰氧基头孢烷酸用途

7-Aminodeacetoxycephalosporanic acid (7-ADCA) 是头孢菌素合成中的关键中间体。

7-氨基去乙酰氧基头孢烷酸名称

[ CAS 号 ]:
22252-43-3

[ 中文名 ]:
7-氨基-3-甲基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸

[ 英文名 ]:
7-Aminodeacetoxycephalosporanic acid

[中文别名 ]:

[英文别名 ]:

Cefadroxil Related Compound B
MFCD00151456
EINECS 244-870-1
7beta-aminodeacetoxycephalosporanic acid
7-Aminodesacetoxycephalosporanic acid
7-ADCA
Cefalexin Impurity 2

7-氨基去乙酰氧基头孢烷酸生物活性

[ 描述 ]:

7-Aminodeacetoxycephalosporanic acid (7-ADCA) 是头孢菌素合成中的关键中间体。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Linda G Otten, et al. Mutational Analysis of a Key Residue in the Substrate Specificity of a Cephalosporin Acylase. Chembiochem. 2004 Jun 7;5(6):820-5.

7-氨基去乙酰氧基头孢烷酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
517.6±50.0 °C at 760 mmHg

[ 熔点 ]:
234ºC (dec.)

[ 分子式 ]:
C₈H₁₀N₂O₃S

[ 分子量 ]:
214.242

[ 闪点 ]:
266.8±30.1 °C

[ 精确质量 ]:
214.041214

[ PSA ]:
108.93000

[ LogP ]:
-0.81

[ 外观性状 ]:
白色至淡黄色结晶粉末

[ 蒸汽压 ]:
0.0±2.9 mmHg at 25°C

[ 折射率 ]:
1.698

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

7-氨基去乙酰氧基头孢烷酸MSDS

详细MSDS(安全技术说明书)

7-氨基去乙酰氧基头孢烷酸安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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7-氨基去乙酰氧基头孢烷酸制备

7-氨基去乙酰氧基头孢烷酸文献

Enhanced enzymatic synthesis of a semi-synthetic cephalosprin, cefaclor, with in situ product removal.

Biotechnol. Lett. 25(14) , 1195-8, (2003)

In the enzymatic synthesis of cefaclor, 3-chloro-7-d-(2-phenylglycinamide)-3-cephem-4-carboxylic acid, from phenylglycine methyl ester and 7-aminodesacetoxymethyl-3-chlorocephalosporanic acid, the in ...

Enzymatic production of cephalexin.

Enzyme Microb. Technol. 16(8) , 715-8, (1994)

Enzymatic production of cephalexin using immobilized penicillin G acylase was studied. The factors that affect the conversion of 7-amino-3-deacetoxycephalosporanic acid (7-ADCA) to cephalexin, such as...

Continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Kinetics of adipoyl-7-aminodeacetoxycephalosporanic acid and byproduct formations.

Biotechnol. Bioeng. 83(3) , 353-60, (2003)

The production kinetics of a transformed strain of Penicillium chrysogenum expressing the expandase gene from Streptomyces clavuligerus was investigated in chemostat cultivations. The recombinant stra...

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