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羟甲基-7-氨基头孢烷酸

羟甲基-7-氨基头孢烷酸名称

[ CAS 号 ]:
6109-70-2

[ 中文名 ]:
羟甲基-7-氨基头孢烷酸

[ 英文名 ]:
Aceclidine hydrochloride

[中文别名 ]:

盐酸醋克利定

[英文别名 ]:

羟甲基-7-氨基头孢烷酸物理化学性质

[ 沸点 ]:
221.5ºC at 760 mmHg

[ 熔点 ]:
166ºC

[ 分子式 ]:
C₉H₁₆ClNO₂

[ 分子量 ]:
205.68200

[ 闪点 ]:
85ºC

[ 精确质量 ]:
205.08700

[ PSA ]:
29.54000

[ LogP ]:
1.38360

[ 外观性状 ]:
white to tan

[ 储存条件 ]:
-20°C Freezer

[ 稳定性 ]:
Moisture Sensitive

[ 水溶解性 ]:
H2O: ≥15mg/mL at ~60°C

羟甲基-7-氨基头孢烷酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VD6198000

CHEMICAL NAME :: 3-Quinuclidinol, acetate (ester), hydrochloride

CAS REGISTRY NUMBER :: 6109-70-2

LAST UPDATED :: 199603

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C9-H15-N-O2.Cl-H

MOLECULAR WEIGHT :: 205.71

WISWESSER LINE NOTATION :: T66 A B CNTJ AOV1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 105 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,322,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 23,398,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 23,398,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 23,398,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 116 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,322,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 23,398,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,322,1968

羟甲基-7-氨基头孢烷酸安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311

[ 警示性声明 ]:
P280-P301 + P310-P312

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ RTECS号 ]:
VD6198000

羟甲基-7-氨基头孢烷酸文献

Double-blind cross-over comparison of aceclidine and pilocarpine in open-angle glaucoma.

Br. J. Ophthalmol. 54(8) , 510-21, (1970)

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