依布硒
依布硒结构式
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常用名 | 依布硒 | 英文名 | Ebselen |
|---|---|---|---|---|
| CAS号 | 60940-34-3 | 分子量 | 274.177 | |
| 密度 | N/A | 沸点 | 402.8±28.0 °C at 760 mmHg | |
| 分子式 | C13H9NOSe | 熔点 | 178-181 °C | |
| MSDS | 中文版 美版 | 闪点 | 197.4±24.0 °C | |
| 符号 |
GHS06, GHS08, GHS09 |
信号词 | Danger |
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Role of reactive oxygen species in transforming growth factor beta1-induced alpha smooth-muscle actin and collagen production in nasal polyp-derived fibroblasts.
Int. Arch. Allergy Immunol. 159(3) , 278-86, (2012) Myofibroblasts are detected in nasal polyps and are involved in nasal polyp formation by inducing extracellular matrix accumulation. Reactive oxygen species (ROS) are released during the differentiation of fibroblasts to myofibroblasts. The purpose of this st... |
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T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.
J. Exp. Med. 212(4) , 555-68, (2015) The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid hydroperoxides. Although Gpx4 represents a key component of the reactive oxygen species-scavenging network, its relevance in the immune system is yet to be defined. Here, we... |
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Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons.
Mol. Cell. Neurosci. 67 , 116-25, (2015) Previous studies have shown that bone morphogenetic proteins (BMPs) promote dendritic growth in sympathetic neurons; however, the downstream signaling molecules that mediate the dendrite promoting activity of BMPs are not well characterized. Here we test the ... |
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Military aircrew and noise-induced hearing loss: prevention and management.
Aviat. Space. Environ. Med. 84(12) , 1268-76, (2013) Modern-day high performance aircraft are more powerful, more efficient, and, unfortunately, frequently produce high noise levels, resulting in noise-induced hearing loss (NIHL) in military aircrew. Military pilots are required to perform many flight duties co... |
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Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity.
Toxicol. Appl. Pharmacol. 258(3) , 394-402, (2012) Chronic, excessive exposure to manganese (Mn) may induce neurotoxicity and cause an irreversible brain disease, referred to as manganism. Efficacious therapies for the treatment of Mn are lacking, mandating the development of new interventions. The purpose of... |
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The glutathione mimic ebselen inhibits oxidative stress but not endoplasmic reticulum stress in endothelial cells.
Life Sci. 134 , 9-15, (2015) Reactive oxygen species are associated with cardiovascular disease, diabetes, and atherosclerosis, yet the use of antioxidants in clinical trials has been ineffective at improving outcomes. In endothelial cells, high-dextrose-induced oxidative stress and endo... |
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Validation of the multiple sensor mechanism of the Keap1-Nrf2 system.
Free Radic. Biol. Med. 53(4) , 817-27, (2012) The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species. Keap1 possesses a number of cysteine residues, some of which are highly reactive and serves as sensors for these insults. Indeed, point mutation... |
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Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose.
J. Biol. Chem. 287(45) , 38210-9, (2012) Thioredoxin reductase 1 (TrxR1) in cytosol is the only known reductant of oxidized thioredoxin 1 (Trx1) in vivo so far. We and others found that aurothioglucose (ATG), a well known active-site inhibitor of TrxR1, inhibited TrxR1 activity in HeLa cell cytosol ... |
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Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.
J. Med. Chem. 56(22) , 9089-99, (2013) A novel series of compounds obtained by fusing the cholinesterase inhibitor donepezil and the antioxidant ebselen were designed as multi-target-directed ligands against Alzheimer's disease. An in vitro assay showed that some of these molecules did not exhibit... |
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Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione.
FASEB J. 27(4) , 1394-403, (2013) Increasing antibiotic resistance makes the identification of new antibacterial principles an urgent task. The thioredoxin system including thioredoxin reductase (TrxR), thioredoxin (Trx), and NADPH plays critical roles in cellular DNA synthesis and defense ag... |