4-羟基-1,5-二甲基-2-苯基-1,2-二氢-3H-吡唑-3-酮
4-羟基-1,5-二甲基-2-苯基-1,2-二氢-3H-吡唑-3-酮结构式
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常用名 | 4-羟基-1,5-二甲基-2-苯基-1,2-二氢-3H-吡唑-3-酮 | 英文名 | 4-hydroxyantipyrine |
|---|---|---|---|---|
| CAS号 | 1672-63-5 | 分子量 | 204.22500 | |
| 密度 | 1.294g/cm3 | 沸点 | 314.3ºC at 760mmHg | |
| 分子式 | C11H12N2O2 | 熔点 | 184-186ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 143.9ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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The effect of age and sex on metabolism and urinary excretion of antipyrine.
J. Gerontol. A. Biol. Sci. Med. Sci. 53(1) , M14-9, (1998) Drug-metabolizing capacity is generally reduced in the elderly. The purpose of this investigation was to study antipyrine clearance and metabolite excretion in old subjects of both sexes.Saliva clearance of antipyrine and the production clearances of antipyri... |
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The pharmacokinetics of antipyrine and three of its metabolites in the rabbit: intravenous administration of pure metabolites.
Pharm. Res. 8(12) , 1470-6, (1991) Antipyrine (AP) is a commonly used probe of oxidative metabolism. Indirect evidence demonstrates formation rate limited disposition of its metabolites. Kinetic studies using antipyrine and its major metabolites 3-hydroxymethylantipyrine (HMA), norantipyrine (... |
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Separation and identification of the 4-hydroxyantipyrine sulphoconjugate.
J. Chromatogr. A. 576(1) , 103-9, (1992) In a previous study we observed, during separation of total antipyrine metabolites by high-performance liquid chromatography and after enzymatic hydrolysis, an unidentified peak corresponding to an ionic compound with pyrazolinone features. In the present stu... |
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Determination of antipyrine and metabolites in plasma of a patient with mild renal failure.
Ther. Drug Monit. 19(6) , 705-10, (1997) A method has been developed for the simultaneous determination of antipyrine and its three major metabolites in plasma of patients with renal failure. Plasma samples (500 microl) were hydrolyzed with beta-glucuronidase/aryl sulphatase. The compounds, after ad... |
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The effect of moderate fluosol-DA hemodilution on gender specific metabolism of antipyrine.
Res. Commun. Chem. Pathol. Pharmacol. 64(3) , 455-62, (1989) Antipyrine metabolism was determined after hemodilution with 40 ml/kg of Fluosol in conscious, unrestrained female and male rats. Rats received an intravenous antipyrine dose (20 mg/kg) 24, 48, or 72 hours after hemodilution and the pharmacokinetic parameters... |
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Influence of short-term water deprivation on antipyrine disposition in calves.
Res. Vet. Sci. 63(1) , 1-3, (1997) The effect of four days water deprivation on the metabolism of antipyrine was studied in female Holstein-Friesian calves, aged 24 to 25 days, by measuring the antipyrine plasma clearance and the excretion of three major metabolites of antipyrine in urine. Wat... |
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Influence of subject age on the inhibition of oxidative metabolism by ciprofloxacin.
Antimicrob. Agents Chemother. 35(1) , 130-4, (1991) Case reports suggest that the magnitude of inhibition of oxidative metabolism produced by ciprofloxacin may be greater in elderly subjects. We examined the effect of oral ciprofloxacin on antipyrine disposition in 13 young (ages, 23 to 34 years) and 9 elderly... |
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Elimination studies of antipyrine and its metabolites in healthy Saudi Arabians.
Hum. Exp. Toxicol. 13(10) , 658-62, (1994) 1. We measured the antipyrine clearance in 18 healthy Saudi subjects and determined the urinary excretion of three of its metabolites: 4-hydroxyantipyrine (4-OH AP), norantipyrine (NOR AP) and 3 hydroxymethylantipyrine (3-OHM AP) in 21 subjects. 2. The mean +... |
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Disposition of antipyrine in patients with extensive metastatic liver disease.
Eur. J. Clin. Pharmacol. 42(5) , 465-9, (1992) In the present study the effect of metastatic liver disease on hepatic drug metabolism has been examined by studying the pharmacokinetics of antipyrine and the urinary excretion of antipyrine and its three major metabolites (4-hydroxyantipyrine, norantipyrine... |
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The effect of cimetidine on antipyrine metabolism in calves.
J. Vet. Pharmacol. Ther. 20(1) , 73-6, (1997)
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