苦鬼臼毒素
苦鬼臼毒素结构式
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常用名 | 苦鬼臼毒素 | 英文名 | Picropodophyllotoxin |
|---|---|---|---|---|
| CAS号 | 477-47-4 | 分子量 | 414.405 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 597.9±50.0 °C at 760 mmHg | |
| 分子式 | C22H22O8 | 熔点 | 225-227ºC | |
| MSDS | 中文版 美版 | 闪点 | 210.2±23.6 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Identification of lipid- and protein-based binders in paintings by direct on-plate wet chemistry and matrix-assisted laser desorption ionization mass spectrometry.
Anal. Bioanal. Chem 407(3) , 1015-22, (2015) Direct on-target plate processing of small (ca. 100 μg) fragments of paint samples for MALDI-MS identification of lipid- and protein-based binders is described. Fragments were fixed on a conventional stainless steel target plate by colloidal graphite followed... |
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The CentriMag centrifugal blood pump as a benchmark for in vitro testing of hemocompatibility in implantable ventricular assist devices.
Artif. Organs 39(2) , 93-101, (2015) Implantable ventricular assist devices (VADs) have proven efficient in advanced heart failure patients as a bridge-to-transplant or destination therapy. However, VAD usage often leads to infection, bleeding, and thrombosis, side effects attributable to the da... |
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TIGAR regulates glycolysis in ischemic kidney proximal tubules.
Am. J. Physiol. Renal Physiol. 308(4) , F298-308, (2015) Tp53-induced glycolysis and apoptosis regulator (TIGAR) activation blocks glycolytic ATP synthesis by inhibiting phosphofructokinase-1 activity. Our data indicate that TIGAR is selectively induced and activated in renal outermedullary proximal straight tubule... |
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Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via insulin-like growth factor-1 receptor-independent mechanism.
Oncotarget 5(18) , 8379-92, (2014) Picropodophyllin (PPP) is an anticancer drug undergoing clinical development in NSCLC. PPP has been shown to suppress IGF-1R signaling and to induce a G2/M cell cycle phase arrest but the exact mechanisms remain to be elucidated. The present study identified ... |
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Monitoring bypassing agent therapy - a prospective crossover study comparing thromboelastometry and thrombin generation assay.
Haemophilia 21(2) , 275-83, (2015) The aim of this study was to evaluate the capability of thromboelastometry (ROTEM) and thrombin generation assay (TGA) to monitor the treatment response of bypassing agent (BPA) therapy and to study whether one method is superior to another. In a prospective ... |
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Thrombin generation assay identifies individual variability in responses to low molecular weight heparin in pregnancy: implications for anticoagulant monitoring.
Br. J. Haematol. 168(5) , 719-27, (2015) Low molecular weight heparin (LMWH) given to inhibit coagulation and reduce the risk of thrombosis, is typically monitored by anti-Xa assay. However, anti-Xa levels may not necessarily provide an accurate measure of coagulation inhibition. Moreover, pregnancy... |
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Picropodophyllin inhibits the growth of Ewing's sarcoma cells through the insulin‑like growth factor‑1 receptor/Akt signaling pathway.
Mol. Med. Report. 12 , 7045-50, (2015) Ewing's sarcoma (ES) is the second most common type of pediatric bone tumor, and is associated with a poor prognosis. Picropodophyllin (PPP), a novel selective inhibitor of insulin‑like growth factor‑1 receptor (IGF‑1R), is able to strongly inhibit various ty... |
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A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation.
ACS Chem. Biol. 10 , 1861-70, (2015) Coagulation factor XII (FXII) inhibitors are of interest for the study of the protease in the intrinsic coagulation pathway, for the suppression of contact activation in blood coagulation assays, and they have potential application in antithrombotic therapy. ... |
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Release of neutrophil extracellular traps by neutrophils stimulated with antiphospholipid antibodies: a newly identified mechanism of thrombosis in the antiphospholipid syndrome.
Arthritis Rheumatology 67 , 2990-3003, (2015) Antiphospholipid antibodies (aPL), especially those targeting β2 -glycoprotein I (β2 GPI), are well known to activate endothelial cells, monocytes, and platelets, with prothrombotic implications. In contrast, the interaction of aPL with neutrophils has not be... |
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Probing ADAMTS13 substrate specificity using phage display.
PLoS ONE 10(4) , e0122931, (2015) Von Willebrand factor (VWF) is a large, multimeric protein that regulates hemostasis by tethering platelets to the subendothelial matrix at sites of vascular damage. The procoagulant activity of plasma VWF correlates with the length of VWF multimers, which is... |