Leukotriene D4
Leukotriene D4结构式
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常用名 | Leukotriene D4 | 英文名 | Leukotriene D4 |
|---|---|---|---|---|
| CAS号 | 73836-78-9 | 分子量 | 496.660 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 748.3±70.0 °C at 760 mmHg | |
| 分子式 | C25H40N2O6S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 406.4±35.7 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.
Nat. Neurosci. 18(1) , 145-53, (2015) The primary sensory system requires the integrated function of multiple cell types, although its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 single mouse neurons to classify them in an unbiased manner, independent of a... |
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Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor.
J. Immunol. 191(12) , 5807-10, (2013) Leukotriene C4 (LTC4) and its extracellular metabolites, LTD4 and LTE4, mediate airway inflammation. They signal through three specific receptors (type 1 cys-LT receptor [CysLT1R], CysLT2R, and GPR99) with overlapping ligand preferences. In this article, we d... |
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A contraction assay system using primary cultured mouse bronchial smooth muscle cells.
Int. Arch. Allergy Immunol. 161 Suppl 2 , 93-7, (2013) Contraction of bronchial smooth muscle is the main mechanism of asthmatic responses. Inflammatory cells such as eosinophils and mast cells produce chemical mediators that induce smooth muscle contraction. To investigate the mechanisms of IgE-independent asthm... |
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Differential cardiotoxicity in response to chronic doxorubicin treatment in male spontaneous hypertension-heart failure (SHHF), spontaneously hypertensive (SHR), and Wistar Kyoto (WKY) rats
Toxicol. Appl. Pharmacol. 273(1) , 47-57, (2013) Life threatening complications from chemotherapy occur frequently in cancer survivors, however little is known about genetic risk factors. We treated male normotensive rats (WKY) and strains with hypertension (SHR) and hypertension with cardiomyopathy (SHHF) ... |
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Modulation of mast cell proliferative and inflammatory responses by leukotriene d4 and stem cell factor signaling interactions.
J. Cell Physiol. 230(3) , 595-602, (2015) Mast cells (MCs) are important effector cells in asthma and pulmonary inflammation, and their proliferation and maturation is maintained by stem cell factor (SCF) via its receptor, c-Kit. Cysteinyl leukotrienes (cys-LTs) are potent inflammatory mediators that... |
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Protein kinase C-mediated phosphorylation of RKIP regulates inhibition of Na-alanine cotransport by leukotriene D(4) in intestinal epithelial cells.
Am. J. Physiol. Cell Physiol. 307(11) , C1010-6, (2014) Leukotriene D4 (LTD4) is an important immune inflammatory mediator that is known to be elevated in the mucosa of chronically inflamed intestine and alter nutrient absorption. LTD4 inhibits Na-alanine cotransport in intestinal epithelial cells by decreasing th... |
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Discovery of montelukast: a once-a-day oral antagonist of leukotriene D4 for the treatment of chronic asthma.
Prog. Med. Chem. 38 , 249-77, (2001)
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Simultaneous quantification of leukotrienes and hydroxyeicosatetraenoic acids in cell culture medium using liquid chromatography/tandem mass spectrometry.
Biomed. Chromatogr. 29 , 1084-93, (2015) Leukotrienes (LTs) and hydroxyeicosatetraenoic acids (HETEs) are important bioactive lipid mediators that participate in various pathophysiological processes. To advance understanding of the mechanisms that regulate these mediators in physiological and pathol... |
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A targeted lipidomics approach to the study of eicosanoid release in synovial joints.
Arthritis. Res. Ther. 13 , R123, (2011) Articular tissues are capable of producing a range of eicosanoid mediators, each of which has individual biological effects and may be affected by anti-inflammatory treatment. We set out to develop and evaluate a high performance liquid chromatography-tandem ... |
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Antigen-induced airway hyperresponsiveness in absence of broncho-obstruction in sensitized guinea pigs.
Exp. Lung Res. 39(3) , 136-45, (2013) Airway obstruction after antigen challenge is not always observed in patients with allergic asthma, even if they develop hyperresponsiveness. A similar event is observed in our guinea pig model of allergic asthma. Our aim was to study this phenomenon.Sensitiz... |