(2S)-2-[(4S)-2-氨基-1,4,5,6-四羟基4-嘧啶基]-N-[[[(1S)-1-羰基-3-甲基丁基]氨基]羰基]甘氨酰-N1-[(1S)-1-甲基-2-氧乙基-L-谷氨酸甲酰胺
![(2S)-2-[(4S)-2-氨基-1,4,5,6-四羟基4-嘧啶基]-N-[[[(1S)-1-羰基-3-甲基丁基]氨基]羰基]甘氨酰-N1-[(1S)-1-甲基-2-氧乙基-L-谷氨酸甲酰胺结构式](https://image.chemsrc.com/caspic/452/51798-45-9.png)
(2S)-2-[(4S)-2-氨基-1,4,5,6-四羟基4-嘧啶基]-N-[[[(1S)-1-羰基-3-甲基丁基]氨基]羰基]甘氨酰-N1-[(1S)-1-甲基-2-氧乙基-L-谷氨酸甲酰胺结构式
|
常用名 | (2S)-2-[(4S)-2-氨基-1,4,5,6-四羟基4-嘧啶基]-N-[[[(1S)-1-羰基-3-甲基丁基]氨基]羰基]甘氨酰-N1-[(1S)-1-甲基-2-氧乙基-L-谷氨酸甲酰胺 | 英文名 | Elastatinal |
|---|---|---|---|---|
| CAS号 | 51798-45-9 | 分子量 | 512.56 | |
| 密度 | 1.44 g/cm3 | 沸点 | N/A | |
| 分子式 | C21H36N8O7 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
|
Elastatinal and leupeptin: effects on u.v.-induced mutation and sister-chromatid exchanges in Chinese hamster cells.
Carcinogenesis 2(4) , 255-9, (1981) Microbial protease inhibitors elastatinal and leupeptin were tested for cytotoxicity and for effects on spontaneous and u.v.-induced 6-thioguanine-resistant (6TGr) mutation and sister-chromatid exchange (SCE) in V79 Chinese hamster cells. Continuous treatment... |
|
|
Reduction of active elastase concentration by means of immobilized inhibitors: a novel therapeutic approach.
Biotechnol. Prog. 20(3) , 968-74, (2004) The inhibitory power of three different active Nylon membranes, separately loaded with three different protease inhibitors, was studied with the aim of reducing the increased elastase concentration occurring during hemodialysis or extracorporeal blood circula... |
|
|
Effects of inhibitors of membrane signal peptide peptidase on protein translocation into membrane vesicles.
Arch. Microbiol. 153(1) , 90-4, (1989) The effect of the removal of signal peptides after cleavage of precursor molecules by the signal peptidase I was examined in an in vitro translocation system with Escherichia coli membrane vesicles. The translocation of periplasmic alkaline phosphatase precur... |
|
|
Comparison of elastolytic activity between experimental aneurysm and experimental diabetes mellitus.
Biol. Pharm. Bull. 21 , 775, (1998) In order to clarify the degradation of elastin under abnormal conditions, we examined the aortic elastolytic activity in rat experimental diabetes mellitus induced by treatment with streptozotocin and in rat experimental aneurysm induced by treatment with an ... |
|
|
Effects of scutellarin on MUC5AC mucin production induced by human neutrophil elastase or interleukin 13 on airway epithelial cells.
J. Korean Med. Sci. 26 , 778-84, (2011) Scutellarin is a flavonoid extracted from a traditional Chinese herb, Erigeron breviscapus. The present study investigated the effect of scutellarin on MUC5AC mucin production and the possible mechanism. Human bronchial epithelial 16 (HBE16) cells were pretre... |
|
|
Oral insulin delivery: the potential of thiolated chitosan-insulin tablets on non-diabetic rats.
J. Control. Release 95(3) , 547-55, (2004) It was the aim of this study to develop a delivery system providing an improved efficacy of orally administered insulin utilizing a thiolated polymer. 2-Iminothiolane was covalently linked to chitosan. The resulting chitosan-TBA (chitosan-4-thiobutylamidine) ... |
|
|
Oral peptide drug delivery: polymer-inhibitor conjugates protecting insulin from enzymatic degradation in vitro.
Biomaterials 21(14) , 1499-507, (2000) A drug-carrier matrix has been developed which protects embedded insulin from degradation by the luminally secreted serine-proteases trypsin (EC 3.4.21.4), chymotrypsin (EC 3.4.21.1) and elastase (EC 3.4.21.36) in vitro. Increasing amounts of the Bowman-Birk ... |
|
|
The effect of low-molecular-weight inhibitors on the growth in vitro of a human pancreatic adenocarcinoma cell line.
Biochem. Soc. Trans. 9(1) , 134, (1981)
|
|
|
Cytotoxic effects of protease inhibitors on human cells. 2. Effect of elastatinal.
Cancer Lett. 10(4) , 301-7, (1980) Effects of elastatinal, a protease inhibitor, on DNA repair and its cytotoxicity were investigated in normal human, xeroderma pigmentosum and Chinese hamster V79 cells. There were no effects of elastatinal on DNA repair and UV-induced sister chromatid exchang... |
|
|
Purification and characterization of the elastase-like enzyme of the bovine granulocyte.
Biochim. Biophys. Acta 615(1) , 237-45, (1980) The extracts of granules isolated from bovine granulocytes show elastase- and chymotrypsin-like activities, as detected with specific synthetic substrates. Extraction of these enzymes depends upon salt concentration. In the course of the present studies a 21-... |