Elastatinal

Modify Date: 2024-01-02 18:20:34

Elastatinal structure	Common Name	Elastatinal
	CAS Number	51798-45-9	Molecular Weight	512.56
	Density	1.44 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₁H₃₆N₈O₇	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Elastatinal

Elastatinal is a potent and competitive inhibitor of elastase, with a Ki of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease[1][2][3][4].

Name	elastatinal
Synonym	More Synonyms

Description	Elastatinal is a potent and competitive inhibitor of elastase, with a Ki of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease[1][2][3][4].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase Research Areas >> Inflammation/Immunology
In Vitro	Elastatinal inhibits the binding of acetyl-alanyl-alanyl-alanine pnitroanilide and acetyl-alanyl-alanyl-alanine methyl ester to elastase, with Kis of 0.24 μM and 0.21 μM, respectively[1]. Elastatinal (5-20 μM) suppresses the enhanced osteoclast differentiation by neutrophils[3].
References	[1]. Umezawa H. Structures and activities of protease inhibitors of microbial origin. Methods Enzymol. 1976;45:678-95. [2]. Feinstein G, et, al. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim Biophys Acta. 1976 May 13;429(3):925-32. [3]. Sugisaki R, et, al. Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin. Bone. 2020 Mar;132:115216. [4]. Vidhya R, et, al. Anti-inflammatory effects of troxerutin are mediated through elastase inhibition. Immunopharmacol Immunotoxicol. 2020 Oct;42(5):423-435.

Density	1.44 g/cm3
Molecular Formula	C₂₁H₃₆N₈O₇
Molecular Weight	512.56
Exact Mass	496.27600
PSA	224.47000
LogP	0.62920
Index of Refraction	1.635
Storage condition	−20°C
Water Solubility	H2O: 20 mg/mL, clear, yellow

Elastatinal MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ9600000

CHEMICAL NAME :: L-Glutamamide, L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-N-(((1- carboxy-3-methylbutyl) amino)carbonyl)glycyl-N(sup 1)-(1-methyl-2-oxoethyl)-, stereoisomer

CAS REGISTRY NUMBER :: 51798-45-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H36-N8-O7

MOLECULAR WEIGHT :: 512.65

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PPTCBY Proceedings of the International Symposium of the Princess Takamatsu Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku, Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 6,57,1976

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LZ9600000

51798-45-9 preparation

Elastatinal and leupeptin: effects on u.v.-induced mutation and sister-chromatid exchanges in Chinese hamster cells.

Carcinogenesis 2(4) , 255-9, (1981)

Microbial protease inhibitors elastatinal and leupeptin were tested for cytotoxicity and for effects on spontaneous and u.v.-induced 6-thioguanine-resistant (6TGr) mutation and sister-chromatid exchan...

Reduction of active elastase concentration by means of immobilized inhibitors: a novel therapeutic approach.

Biotechnol. Prog. 20(3) , 968-74, (2004)

The inhibitory power of three different active Nylon membranes, separately loaded with three different protease inhibitors, was studied with the aim of reducing the increased elastase concentration oc...

Effects of inhibitors of membrane signal peptide peptidase on protein translocation into membrane vesicles.

Arch. Microbiol. 153(1) , 90-4, (1989)

The effect of the removal of signal peptides after cleavage of precursor molecules by the signal peptidase I was examined in an in vitro translocation system with Escherichia coli membrane vesicles. T...

elastatinal from microbial source

Leu-co-cpd-Gln-Ala-h

Elastatinal

EINECS 257-426-7

DC Chemicals Limited
China
Product Name: Elastatinal
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Elastatinal

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Elastatinal Biological Activity

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HEALTH HAZARD DATA

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