倒千里光碱
倒千里光碱结构式
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常用名 | 倒千里光碱 | 英文名 | isatidine |
|---|---|---|---|---|
| CAS号 | 480-54-6 | 分子量 | 351.394 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 583.2±50.0 °C at 760 mmHg | |
| 分子式 | C18H25NO6 | 熔点 | 208-211ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 306.5±30.1 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Diversity of pyrrolizidine alkaloids in native and invasive Senecio pterophorus (Asteraceae): implications for toxicity.
Phytochemistry 108 , 137-46, (2014) Changes in plant chemical defenses after invasion could have consequences on the invaded ecosystems by modifying the interactions between plants and herbivores and facilitating invasion success. However, no comprehensive biogeographical studies have yet deter... |
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Involvement of organic cation transporter 1 and CYP3A4 in retrorsine-induced toxicity.
Toxicology 322 , 34-42, (2014) Retrorsine (RTS) is a hepatotoxic pyrrolizidine alkaloid present in plants of the Senecio genus. The present study is aimed at clarifying the role of organic cation transporters (OCTs) in the liver disposition of RTS, and the coupling of OCT1 and cytochrome P... |
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Are effects of common ragwort in the Ames test caused by pyrrolizidine alkaloids?
Mutat. Res. 778 , 1-10, (2015) It has previously been demonstrated by others that acetone extracts of Senecio jacobaea (syn. Jacobaea vulgaris, common or tansy ragwort) test positive in the Salmonella/microsome mutagenicity test (Ames test). Pyrrolizidine alkaloids (PAs) are thought to be ... |
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The growth pattern of transplanted normal and nodular hepatocytes.
Histochem. Cell Biol. 135 , 581-91, (2011) Overt neoplasia is often the end result of a long biological process beginning with the appearance of focal lesions of altered tissue morphology. While the putative clonal nature of focal lesions has often been emphasized, increasing attention is being devote... |
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Hepatocytes from fibrotic liver possess high growth potential in vivo.
Cell. Transplant. 18(5) , 665-75, (2009) Hepatocyte transplantation is effective for treating liver failure, but healthy donors as a source of hepatocytes are quite limited. The livers of patients with hepatic fibrosis could be an alternative source; however, few reports have examined the nature of ... |
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Polyploidization without mitosis improves in vivo liver transduction with lentiviral vectors.
Hum. Gene Ther. 24(2) , 143-51, (2013) Lentiviral vectors are efficient gene delivery vehicles for therapeutic and research applications. In contrast to oncoretroviral vectors, they are able to infect most nonproliferating cells. In the liver, induction of cell proliferation dramatically improved ... |
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Retrorsine, but not monocrotaline, is a mechanism-based inactivator of P450 3A4.
Chem. Biol. Interact. 183(1) , 49-56, (2010) Retrorsine (RTS) and monocrotaline (MCT) cause severe toxicities via P450-mediated metabolic activation. The screening of mechanism-based inhibitors showed RTS inactivated 3A4 in the presence of NADPH. Unlike RTS, MCT failed to inhibit P450 3A4 and other enzy... |
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Normal hepatocyte transplantation delays the emergence of chemically induced preneoplastic nodules in rat liver.
Cell. Transplant. 21(4) , 671-7, (2012) Cancer often arises in a background of chronic tissue damage. It is also increasingly appreciated that such an injured tissue microenvironment might foster the selective emergence of altered cells, leading to neoplasia. Accordingly, reversal of chronic tissue... |
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Liver regeneration by small hepatocyte-like progenitor cells after necrotic injury by carbon tetrachloride in retrorsine-exposed rats.
Exp. Mol. Pathol. 89(2) , 92-8, (2010) Liver regeneration after partial hepatectomy (PH) in rats exposed to the pyrrolizidine alkaloid retrorsine is accomplished through the proliferation and differentiation of a population of small hepatocyte-like progenitor cells (SHPCs). The activation, emergen... |
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Cytokine-dependent activation of small hepatocyte-like progenitor cells in retrorsine-induced rat liver injury.
Exp. Mol. Pathol. 88(1) , 7-14, (2010) Complete liver regeneration after partial hepatectomy (PH) in rats exposed to the pyrrolizidine alkaloid retrorsine is accomplished through the activation, expansion, and differentiation of a population of small hepatocyte-like progenitor cells (SHPCs). The m... |