克拉霉素
克拉霉素结构式
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常用名 | 克拉霉素 | 英文名 | Clarithromycin |
|---|---|---|---|---|
| CAS号 | 81103-11-9 | 分子量 | 747.953 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 805.5±65.0 °C at 760 mmHg | |
| 分子式 | C38H69NO13 | 熔点 | 217-220ºC | |
| MSDS | 中文版 美版 | 闪点 | 440.9±34.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Environmental friendly method for urban wastewater monitoring of micropollutants defined in the Directive 2013/39/EU and Decision 2015/495/EU.
J. Chromatogr. A. 1418 , 140-9, (2015) The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of 37 micropollutants including Priority Substances (Directiv... |
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Dissolution enhancement and in vitro performance of clarithromycin nanocrystals produced by precipitation-lyophilization-homogenization method.
Eur. J. Pharm. Biopharm. 88(3) , 886-96, (2014) The gastroduodenal diseases caused by Helicobacter pylori were commonly treated with antibiotic clarithromycin as a standard regimen. According to the poorly water-soluble of clarithromycin, the nanocrystal formulation was prepared. The aim of this study was ... |
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Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry.
J. Pharm. Biomed. Anal. 102 , 9-16, (2014) A simple and accurate liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method for the quantitation of 20 anti-tuberculosis (anti-TB) drugs in human plasma, was developed as a tool for therapeutic drug monitoring. Two protein precipitation methods w... |
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Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges".
Int. J. Cancer 136(4) , E188-96, (2015) ATP-binding cassette (ABC) drug transporters consuming ATPs for drug efflux is a common mechanism by which clinical cancers develop multidrug resistance (MDR). We hypothesized that MDR phenotypes could be suppressed by administration of "ersatzdroges," nonche... |
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In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383.
Pharm. Res. 32 , 3937-51, (2015) To assess accumulation and lysosomal sequestration of 9 drugs used in respiratory indications (plus imipramine as positive control) in the alveolar macrophage (AM) cell line NR8383.For all drugs, uptake at 5 μM was investigated at 37 and 4°C to delineate acti... |
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Helicobacter pylori antimicrobial resistance rates in the central region of Portugal.
Clin. Microbiol. Infect. 20(11) , 1127-33, (2014) Helicobacter pylori resistance to antimicrobial agents is steadily increasing. It is extremely important to be aware of the local prevalence of antibiotic resistance so as to adjust treatment strategies. During this single-centre, prospective study, we aimed ... |
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Use of selected lactic acid bacteria in the eradication of Helicobacter pylori infection.
J. Microbiol. 52(11) , 955-62, (2014) Helicobacter pylori is among the major pathogenic bacteria that cause chronic gastritis and peptic ulcer disease and is related to the development of gastric cancer. Several chemicals, including antibiotics, have been used to eradicate H. pylori; however, the... |
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A comparative study of sequential therapy and standard triple therapy for Helicobacter pylori infection: a randomized multicenter trial.
Am. J. Gastroenterol. 109(4) , 535-41, (2014) Studies conducted in large populations of patients and providing full information on Helicobacter pylori (H. pylori) antibiotic resistance are needed to determine the efficacy of sequential therapy (SQT) against this pathogen. This study compared eradication ... |
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Preventing metachronous gastric lesions after endoscopic submucosal dissection through Helicobacter pylori eradication.
J. Gastroenterol. Hepatol. 30(1) , 75-81, (2014) Metachronous recurrence often occurs after endoscopic submucosal dissection for early gastric cancer, and a method for preventing recurrence is unknown. We aimed to identify risk factors for metachronous lesions, and the effects of aspirin use and Helicobacte... |
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Inhibitory effects of emodin, baicalin, schizandrin and berberine on hefA gene: treatment of Helicobacter pylori-induced multidrug resistance.
World J. Gastroenterol. 21(14) , 4225-31, (2015) To investigate the inhibitory effects of emodin, baicalin, etc. on the hefA gene of multidrug resistance (MDR) in Helicobacter pylori (H. pylori).The double dilution method was used to screen MDR H. pylori strains and determine the minimum inhibitory concentr... |