4-雄烯-11β-醇-3,17-二酮
4-雄烯-11β-醇-3,17-二酮结构式
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常用名 | 4-雄烯-11β-醇-3,17-二酮 | 英文名 | 11-Beta-hydroxyandrostenedione |
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| CAS号 | 382-44-5 | 分子量 | 302.408 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 475.3±45.0 °C at 760 mmHg | |
| 分子式 | C19H26O3 | 熔点 | 197-199℃ | |
| MSDS | 中文版 美版 | 闪点 | 255.4±25.2 °C |
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11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione
J. Steroid Biochem. Mol. Biol. 138 , 132-42, (2013) • Etomidate inhibited DOC, deoxycortisol, A4 and T conversion in H295R cells. • CYP11B1 11β-hydroxylates A4 and T; CYP11B2 11β-hydroxylates T. • 11βHSD1 converts 11KA4 and 11KT; 11βHSD2 converts 11OHA4 and 11OHT. • Steroid 5α-reductase types 1 and 2 convert 1... |
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Oxygen availability as a regulatory factor of androgen synthesis by adrenocortical cells.
Endocrinology 132(1) , 255-60, (1993) Molecular oxygen is an obligatory substrate of all cytochrome P-450 (cyt P-450) hydroxylases involved in the steroid biosynthetic pathways. However, oxygen-derived free radicals are highly destructive species resulting from cyt P-450-catalyzed steroid hydroxy... |
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11beta-hydroxyandrostenedione and delta5-androstenediol as markers of adrenal androgen production in patients with 21-hydroxylase-deficient nonclassic adrenal hyperplasia.
Fertil. Steril. 72(6) , 996-1000, (1999) To determine the sensitivity of 11beta-hydroxyandrostenedione (11-OHA4) and delta5-androstenediol (ADIOL) as markers of excessive adrenal androgen production.Prospective study.Academic medical centers.Thirteen women with untreated 21-hydroxylase-deficient non... |
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Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men.
Exp. Clin. Endocrinol. 100(3) , 117-9, (1992) In order to assess the contribution of individual steroidogenic organs to over-all steroid biosynthesis, the basal plasma levels of six hormonal steroids, reflecting the function of gonads and adrenals, as well as both gonadotropins and prolactin, have been d... |
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Transforming growth factor beta1 inhibits aldosterone and cortisol production in the human adrenocortical cell line NCI-H295R through inhibition of CYP11B1 and CYP11B2 expression.
J. Endocrinol. 176(1) , 69-82, (2003) Transforming growth factor beta1 (TGFbeta1) has been shown to exert strong inhibitory effects on adrenocortical cell steroidogenesis. However, the molecular targets of TGFbeta1 in adrenocortical cells appear to differ between species. Here, we report the firs... |
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Sources of elevated serum androgens in postmenopausal women who develop breast cancer.
Cancer Epidemiol. Biomarkers Prev. 10(4) , 407-10, (2001) Postmenopausal women with elevated serum androgens are at an increased risk of breast cancer. High dehydroepiandrosterone sulfate concentrations in these women suggest increased adrenal secretion. Both the adrenals and ovaries could contribute to elevated con... |
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A quantitative HPLC-MS method for the simultaneous determination of testosterone, 11-ketotestosterone and 11-beta hydroxyandrostenedione in fish serum.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(14-15) , 1509-15, (2009) A simple and novel HPLC-MS method for the simultaneous quantification of testosterone, 11-ketotestosterone, and 11beta-hydroxyandrostenedione in fish serum was developed and validated. Separation was achieved on a C-18 column using a water-acetonitrile mobile... |
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A primary adrenal steroid, 11beta-hydroxyandrostenedione, has an osteotropic effect and little androgenic activity.
J. Steroid Biochem. Mol. Biol. 74(4) , 203-11, (2000) The physiological role of 11beta hydroxy-androstenedione (11betaOHA), a primary adrenal steroid, remains unknown. In the present study, we investigated the effect of 11betaOHA on bone metabolism in vitro and in vivo. Administration of 11betaOHA enhanced the c... |
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Studies to confirm the source of 11 beta-hydroxyandrostenedione.
J. Steroid Biochem. Mol. Biol. 41(3-8) , 875-80, (1992) In a longitudinal study of 82 children we found a gradual rise in median plasma concentrations of 11 beta-hydroxyandrostenedione (11 beta-OH-A4) from 2.5 to 6.4 nmol/l during childhood which was similar in both sexes. This could reflect changes in adrenal fun... |
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Daily variation of serum cortisol, 17-hydroxyprogesterone and five androgens in healthy women.
Braz. J. Med. Biol. Res. 28(4) , 485-90, (1995) Serum cortisol, 17-hydroxyprogesterone and five androgens (androstenedione, 11-hydroxyandrostenedione, dehydroepiandrosterone and its sulphate, and testosterone) were measured by radioimmunoassay at 8:00, 16:00, 20:00 and 24:00 h and again at 8:00 h on the ne... |