11-Beta-hydroxyandrostenedione
Modify Date: 2024-01-04 18:04:40
11-Beta-hydroxyandrostenedione structure
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Common Name | 11-Beta-hydroxyandrostenedione | ||
|---|---|---|---|---|
| CAS Number | 382-44-5 | Molecular Weight | 302.408 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 475.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C19H26O3 | Melting Point | 197-199℃ | |
| MSDS | Chinese USA | Flash Point | 255.4±25.2 °C | |
Use of 11-Beta-hydroxyandrostenedione11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism[1][2]. |
| Name | 11β-hydroxyandrost-4-ene-3,17-dione |
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| Synonym | More Synonyms |
| Description | 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism[1][2]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively[2]. |
| In Vivo | The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 475.3±45.0 °C at 760 mmHg |
| Melting Point | 197-199℃ |
| Molecular Formula | C19H26O3 |
| Molecular Weight | 302.408 |
| Flash Point | 255.4±25.2 °C |
| Exact Mass | 302.188202 |
| PSA | 54.37000 |
| LogP | 1.27 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.569 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3.0 |
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11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione
J. Steroid Biochem. Mol. Biol. 138 , 132-42, (2013) • Etomidate inhibited DOC, deoxycortisol, A4 and T conversion in H295R cells. • CYP11B1 11β-hydroxylates A4 and T; CYP11B2 11β-hydroxylates T. • 11βHSD1 converts 11KA4 and 11KT; 11βHSD2 converts 11OHA... |
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Oxygen availability as a regulatory factor of androgen synthesis by adrenocortical cells.
Endocrinology 132(1) , 255-60, (1993) Molecular oxygen is an obligatory substrate of all cytochrome P-450 (cyt P-450) hydroxylases involved in the steroid biosynthetic pathways. However, oxygen-derived free radicals are highly destructive... |
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11beta-hydroxyandrostenedione and delta5-androstenediol as markers of adrenal androgen production in patients with 21-hydroxylase-deficient nonclassic adrenal hyperplasia.
Fertil. Steril. 72(6) , 996-1000, (1999) To determine the sensitivity of 11beta-hydroxyandrostenedione (11-OHA4) and delta5-androstenediol (ADIOL) as markers of excessive adrenal androgen production.Prospective study.Academic medical centers... |
| (8S,9S,10R,11S,13S,14S)-11-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione |
| Androst-4-ene-3,17-dione, 11β-hydroxy- |
| U 2826 |
| Androst-4-ene-3,17-dione, 11-hydroxy-, (11β)- |
| 11β-hydroxyandrost-4-ene-3,17-dione |
| (11β)-11-Hydroxyandrost-4-ene-3,17-dione |
| 4-Androsten-11beta-ol-3,17-dione |
| 11beta-Hydroxyandrostenedione |
| 11β-Hydroxy-4-androsten-3,17-dione |
| 11beta-Hydroxyandrost-4-ene-3,17-dione |
| Androst-4-ene-3,17-dione-11beta-ol |
| 11b-Hydroxyandrost-4-ene-3,17-dione |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 11-Beta-hydroxyandrostenedione
- Price: ￥6718.0/250mg ￥778.0/10mg ￥2018.0/50mg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: 11-Beta-hydroxyandrostenedione
- Price:
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
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Price: ￥1633/10 mM * 1 mL in DMSO
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