The Journal of Steroid Biochemistry and Molecular Biology 2013-11-01

11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione

Amanda C. Swart, Lindie Schloms, Karl-Heinz Storbeck, Liezl M. Bloem, Therina du Toit, Jonathan L. Quanson, William E. Rainey, Pieter Swart

Index: J. Steroid Biochem. Mol. Biol. 138 , 132-42, (2013)

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Abstract

• Etomidate inhibited DOC, deoxycortisol, A4 and T conversion in H295R cells. • CYP11B1 11β-hydroxylates A4 and T; CYP11B2 11β-hydroxylates T. • 11βHSD1 converts 11KA4 and 11KT; 11βHSD2 converts 11OHA4 and 11OHT. • Steroid 5α-reductase types 1 and 2 convert 11OHA4 to 11β-OH-5α-androstanedione. • In LNCaP cells 11OHA4 is metabolized to 11β-OH-5α-androstanedione, 11KA4 and 11KT.