Top Suppliers:I want be here
Related CAS#:
382-44-5 2331287-27-3
3386-04-7 76583-06-7
516-41-6 51259-83-7
3494-53-9 71794-60-0
1164-86-9 3924-22-9
2172207-61-1 2171817-38-0
2171977-64-1 2171687-46-8
2172042-48-5 2114072-84-1
2171418-15-6 2748233-93-2
2171817-45-9 2172042-58-7

382-44-5

382-44-5 structure
382-44-5 structure
  • Name: 11-Beta-hydroxyandrostenedione
  • Chemical Name: 11β-hydroxyandrost-4-ene-3,17-dione
  • CAS Number: 382-44-5
  • Molecular Formula: C19H26O3
  • Molecular Weight: 302.408
  • Catalog: Research Areas Endocrinology
  • Create Date: 2018-11-26 11:39:46
  • Modify Date: 2025-08-22 23:50:56
  • 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism[1][2].
Name 11β-hydroxyandrost-4-ene-3,17-dione
Synonyms (8S,9S,10R,11S,13S,14S)-11-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
Androst-4-ene-3,17-dione, 11β-hydroxy-
U 2826
Androst-4-ene-3,17-dione, 11-hydroxy-, (11β)-
11β-hydroxyandrost-4-ene-3,17-dione
(11β)-11-Hydroxyandrost-4-ene-3,17-dione
4-Androsten-11beta-ol-3,17-dione
11beta-Hydroxyandrostenedione
11β-Hydroxy-4-androsten-3,17-dione
11beta-Hydroxyandrost-4-ene-3,17-dione
Androst-4-ene-3,17-dione-11beta-ol
11b-Hydroxyandrost-4-ene-3,17-dione
Description 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism[1][2].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively[2].
In Vivo The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism[1].
References

[1]. Ibrahim F, et al. Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer. J Steroid Biochem Mol Biol. 2003 Apr;84(5):563-8.

[2]. Rachelle Gent, et al. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17αhydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol
Density 1.2±0.1 g/cm3
Boiling Point 475.3±45.0 °C at 760 mmHg
Melting Point 197-199℃
Molecular Formula C19H26O3
Molecular Weight 302.408
Flash Point 255.4±25.2 °C
Exact Mass 302.188202
PSA 54.37000
LogP 1.27
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.569
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3.0
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:382-44-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 382-44-5 | Chemsrc address: https://www.chemsrc.com/en/baike/951209.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved