安替比林
安替比林结构式
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常用名 | 安替比林 | 英文名 | Antipyrine |
|---|---|---|---|---|
| CAS号 | 60-80-0 | 分子量 | 188.226 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 319.0±0.0 °C at 760 mmHg | |
| 分子式 | C11H12N2O | 熔点 | 109-111 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 114.8±15.0 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
J. Med. Chem. 48 , 3269-79, (2005) Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm of the partition coefficient of the neutral species in the... |
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The free radical scavenger, edaravone, ameliorates delayed neuropsychological sequelae after acute carbon monoxide poisoning in rabbits.
Undersea Hyperb. Med. 40(3) , 223-9, (2013) The mechanism underlying delayed neuropsychological sequelae (DNS) after acute carbon monoxide (CO) poisoning is unclear. There are no effective treatments for DNS. As part of a new generation of antioxidants, edaravone has been reported to improve clinical o... |
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Protective effect of edaravone against Alzheimer's disease-relevant insults in neuroblastoma N2a cells.
Neurosci. Lett. 531(2) , 160-5, (2012) Oxidative stress has been demonstrated to be involved in the pathogenesis of Alzheimer's disease (AD). Thus, antioxidant therapy may represent a promising avenue for the treatment of AD. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a potent free radical... |
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Edaravone alleviates hypoxia-acidosis/reoxygenation-induced neuronal injury by activating ERK1/2
Neurosci. Lett. 543 , 72-7, (2013) • Hypoxia-acidosis/reoxygenation (H-A/R) exposure triggers neuronal injury. • Edaravone alleviates H-A/R-induced neuronal injury. • ERK1/2 activation is involved in the process of edaravone neuroprotection. |
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Differential induction of cytochrome P450 isoforms and peroxisomal proliferation by cyfluthrin in male Wistar rats.
Toxicol. Lett. 220(2) , 135-42, (2013) Cyfluthrin effects on in vivo drug metabolizing enzymes were evaluated using the oxidative substrate antipyrine. Antipyrine pharmacokinetics in plasma and urinary excretion of its major metabolites with and without cyfluthrin oral treatment (20mg/kg/day for 6... |
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Synthesis, structure and photoresponsive properties of 4-(3-fluorobenzylideneamino)antipyrine.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 113 , 43-51, (2013) Organic compounds are attracting greater attention largely in the recent years owing to their potential applications in the functional materials. Herein we reported the structural and photophysical properties of 4-(3-fluorobenzylideneamino)antipyrine. The stu... |
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Ultrasound-promoted greener synthesis of novel trifurcate 3-substituted-chroman-2,4-dione derivatives and their drug-likeness evaluation.
Molecules 17(12) , 14146-58, (2012) An efficient and convenient approach for one-pot synthesis of 3-substituted chroman-2,4-diones via a three-component reaction of aromatic aldehydes, 4-hydroxy-coumarins and diverse pyrazolone derivatives was described. The combinatorial synthesis for this met... |
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Aminophylline, administered at usual doses for rodents in pharmacological studies, induces hippocampal neuronal cell injury under low tidal volume hypoxic conditions in guinea-pigs.
J. Pharm. Pharmacol. 65(1) , 102-14, (2013) To establish whether aminophylline, administered at usual doses for rodents in pharmacological studies, induces brain injury in systemic hypoxaemia in guinea-pigs. A hypoxaemia (partial oxygen tension of arterial blood (PaO₂) = 40-60 mmHg) model was developed... |
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[Metabolism of antipyrine in man].
Pathol. Biol. 33(7) , 777-80, (1985) Antipyrine is widely used as a model compound to assess the hepatic metabolism in man. This drug is extensively metabolized by the hepatic microsomal drug-oxidizing system, into three main metabolites and six minor compounds of the phase I. The metabolite fat... |
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Robust calibration models to predict antipyrine content in various kinds of packaged hospital powder preparations by using near-infrared spectroscopy.
Biomed Mater Eng 22(5) , 311-9, (2012) The purpose of this study was to evaluate drug content of hospital powder preparations using non-destructive, non-contact, short-term measurements with near-infrared spectroscopy (NIR). Antipyrine (0-50%) was mixed with additive powder, and packed with semi-t... |