盐酸洛哌丁胺
盐酸洛哌丁胺结构式
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常用名 | 盐酸洛哌丁胺 | 英文名 | Loperamide hydrochloride |
|---|---|---|---|---|
| CAS号 | 34552-83-5 | 分子量 | 513.498 | |
| 密度 | N/A | 沸点 | 647.2ºC at 760 mmHg | |
| 分子式 | C29H34Cl2N2O2 | 熔点 | 223-225°C | |
| MSDS | 中文版 美版 | 闪点 | 345.2ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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Salt effects in electromembrane extraction.
J. Chromatogr. A. 1347 , 1-7, (2014) Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs ... |
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Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates.
J. Pharmacol. Exp. Ther. 351(3) , 576-84, (2014) Dietary substances, including herbal products and citrus juices, can perpetrate interactions with conventional medications. Regulatory guidances for dietary substance-drug interaction assessment are lacking. This deficiency is due in part to challenges unique... |
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Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.
J. Chromatogr. A. 1374 , 122-33, (2014) The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicable, high-throughput, easy-to-use chromatographic method, wi... |
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Cell-free microfluidic determination of P-glycoprotein interactions with substrates and inhibitors.
Pharm. Res. 31(12) , 3415-25, (2014) The membrane protein P-glycoprotein (P-gp) plays key roles in the oral bioavailability of drugs, their blood brain barrier passage as well as in multidrug resistance. For new drug candidates it is mandatory to study their interaction with P-gp, according to F... |
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Does the gastroprotective action of a medicinal plant ensure healing effects? An integrative study of the biological effects of Serjania marginata Casar. (Sapindaceae) in rats.
J. Ethnopharmacol. 172 , 312-24, (2015) Serjania marginata (Sapindaceae), a medicinal plant commonly found in the Brazilian Cerrado, Paraguay, Bolivia and Argentina, is also known as "cipó-uva" or "cipó-timbó". Ethnopharmacological studies indicate that the leaves from this medicinal plant are used... |
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Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay.
PLoS ONE 9(10) , e110800, (2014) Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole. Chloroquine accumulat... |
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Development of orodispersible polymer films with focus on the solid state characterization of crystalline loperamide.
Eur. J. Pharm. Biopharm. 94 , 52-63, (2015) The formulation of active pharmaceutical ingredients (API) as orodispersible films is gaining interest among novel oral drug delivery systems due to their small size, enhanced flexibility and improved patient compliance. The aim of this work was the preparati... |
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Metformin as adjunct antituberculosis therapy.
Sci. Transl. Med. 6(263) , 263ra159, (2014) The global burden of tuberculosis (TB) morbidity and mortality remains immense. A potential new approach to TB therapy is to augment protective host immune responses. We report that the antidiabetic drug metformin (MET) reduces the intracellular growth of Myc... |
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Antidiarrheal activity of cashew GUM, a complex heteropolysaccharide extracted from exudate of Anacardium occidentale L. in rodents.
J. Ethnopharmacol. 174 , 299-307, (2015) Anacardium occidentale L. (Anacardiaceae) is commonly known as the cashew tree. It is native to tropical America and extracts of the leaves, bark, roots, chestnut net and exudate have been traditionally used in northeast Brazil for the treatment of various di... |
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Comparison of the effects of clonidine, loperamide and metoclopramide in two models of gastric emptying in the rat.
Fundam. Clin. Pharmacol. 29(1) , 86-94, (2015) Several methods are used to evaluate gastric emptying (GE) in rats, which is an important endpoint in preclinical drug development. Although phenol red model or monitoring of plasma acetaminophen levels are well-established procedures for GE assessment, their... |