氯诺昔康
氯诺昔康结构式
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常用名 | 氯诺昔康 | 英文名 | Lornoxicam |
|---|---|---|---|---|
| CAS号 | 70374-39-9 | 分子量 | 371.819 | |
| 密度 | 1.7±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C13H10ClN3O4S2 | 熔点 | 225-230°C (dec.) | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS06 |
信号词 | Danger |
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Intra-articular levobupivacaine, lornoxicam and morphine analgesia after knee arthroscopy: a randomized, controlled trial.
Acta Orthop. Traumatol. Turc. 46(6) , 411-5, (2012) The aim of this study was to compare the analgesic effects of intra-articular levobupivacaine alone, intra-articular levobupivacaine in combination with lornoxicam, and intra-articular levobupivacaine in combination with lornoxicam and morphine on patients fo... |
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Characterization of two polymorphs of lornoxicam.
J. Pharm. Pharmacol. 65(1) , 44-52, (2013) The aim of the study was to prepare and to characterize two polymorphs of lornoxicam, a water-insoluble non-steroidal anti-inflammatory drug, which has thus far received no exploration of its polymorphs.Form I and form II of lornoxicam were prepared by recrys... |
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Investigation on the micelle-sensitized Ce(IV)-lornoxicam-Rh B chemiluminescence system and its application.
J. Fluoresc. 22(1) , 529-35, (2012) Based on the micelle synergism mechanism, a simple and sensitive flow injection chemiluminescence (FI-CL) method for the assay of lornoxicam was described. The CL signal generated from the reaction of Ce (IV) with lornoxicam in acidic solution was very weak, ... |
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Enhanced targeting efficiency of PLGA microspheres loaded with Lornoxicam for intra-articular administration.
Drug Deliv. 18(7) , 536-44, (2011) Owing to its rationale of targeting the drug to the site of action and minimizing systemic toxic effects of the drug, intra-articular drug delivery system has gained growing interests. In this study, emphasis was placed on intra-articular Lornoxicam-loaded PL... |
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Overview of the pharmacological properties, pharmacokinetics and animal safety assessment of lornoxicam.
Postgrad. Med. J. 66 Suppl 4 , S18-21, (1990) Lornoxicam is a new, highly potent antirheumatic agent which is an oxicam derivative. Although highly potent as a cyclo-oxygenase inhibitor, the compound does not cause inhibition of 5-lipoxygenase and does not appear to shunt arachidonic acid through this ca... |
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Intra-articular lornoxicam loaded PLGA microspheres: enhanced therapeutic efficiency and decreased systemic toxicity in the treatment of osteoarthritis.
Drug Deliv. 19(5) , 255-63, (2012) The aim of this study was to investigate the joint tissue distribution and pharmacodynamics of Lornoxicam (Lnxc) following intra-articular injection of either Lnxc suspensions or sustained release Lnxc-loaded PLGA microspheres (Lnxc-MS), as well as the biocom... |
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Preoperative peritonsillar lornoxicam infiltration is not superior to intravenous lornoxicam for pain relief following tonsillectomy in adults.
Eur. J. Anaesthesiol. 27(9) , 807-11, (2010) Nonsteroidal anti-inflammatory drugs have peripheral analgesic effects. We compared the efficacy of peritonsillar infiltration versus intravenous (i.v.) lornoxicam on pain relief after tonsillectomy in adults.Sixty adult patients scheduled for tonsillectomy w... |
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Clinical pharmacokinetic studies with lornoxicam.
Postgrad. Med. J. 66 Suppl 4 , S28-9, (1990) Pharmacokinetic data from several studies in young and elderly human subjects are reviewed. Lornoxicam appears to be extensively metabolized and no unchanged drug has been found in the urine. It has a relatively short elimination half-life (about 4 hours), an... |
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Clinical pharmacological studies of some possible interactions of lornoxicam with other drugs.
Postgrad. Med. J. 66 Suppl 4 , S30-4, (1990) A series of studies in human subjects of potential interactions of lornoxicam with some other drugs is reviewed. No evidence of kinetic interaction was found with the antacids Maalox or Solugastrol, nor was there evidence of influence on antipyrine clearance.... |
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Effects of the CYP2C9*1/*13 genotype on the pharmacokinetics of lornoxicam.
Basic Clin Pharmacol Toxicol. 109(6) , 476-80, (2011) Lornoxicam is extensively metabolized by CYP2C9, and a CYP2C9*13 is one of the principal variant alleles in East Asian populations. The aim of this study was to evaluate the effects of CYP2C9*1/*13 on the pharmacokinetic parameters of lornoxicam in healthy in... |