磷酸氯喹
磷酸氯喹结构式
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常用名 | 磷酸氯喹 | 英文名 | Chloroquine diphosphate |
|---|---|---|---|---|
| CAS号 | 50-63-5 | 分子量 | 515.862 | |
| 密度 | N/A | 沸点 | 460.6ºC at 760 mmHg | |
| 分子式 | C18H32ClN3O8P2 | 熔点 | 200 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 232.3ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.
Autophagy 10(7) , 1241-55, (2014) Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazole, a traditional antifungal drug, has been identified as a ... |
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Regulators of autophagosome formation in Drosophila muscles.
PLoS Genet. 11(2) , e1005006, (2015) Given the diversity of autophagy targets and regulation, it is important to characterize autophagy in various cell types and conditions. We used a primary myocyte cell culture system to assay the role of putative autophagy regulators in the specific context o... |
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An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease.
Mol. Pharmacol. 87(2) , 323-37, (2015) The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime viral mRNA synthesis, is a promising target for novel anti-influenza virus therapeutics. The catalytic center of this enzyme resides in the N-terminal part of PA (PA-Nter) a... |
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Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells.
J. Pineal Res. 59 , 178-89, (2015) Autophagy is a process that maintains homeostasis during stress, although it also contributes to cell death under specific contexts. Ceramides have emerged as important effectors in the regulation of autophagy, mediating the crosstalk with apoptosis. Melatoni... |
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Quantitation of secreted proteins using mCherry fusion constructs and a fluorescent microplate reader.
Anal. Biochem. 473 , 34-40, (2015) Traditional assays for secreted proteins include methods such as Western blot and enzyme-linked immunosorbent assay (ELISA) detection of the protein in the cell culture medium. We describe a method for the detection of a secreted protein based on fluorescent ... |
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Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model.
Malaria Journal 14 , 8, (2015) Even though malaria is a completely preventable and treatable disease, it remains a threat to human life and a burden to the global economy due to the emergence of multiple-drug resistant malaria parasites. According to the World Malaria Report 2013, in 2012 ... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme.
Autophagy 10(8) , 1359-68, (2014) Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine the maximum tolerated dose (MTD) and efficacy of HCQ in combination with rad... |
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Fungal recognition enhances mannose receptor shedding through dectin-1 engagement.
J. Biol. Chem. 286(10) , 7822-9, (2011) The mannose receptor (MR) is an endocytic type I membrane molecule with a broad ligand specificity that is involved in both hemostasis and pathogen recognition. Membrane-anchored MR is cleaved by a metalloproteinase into functional soluble MR (sMR) composed o... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |