7-硝基吲唑
7-硝基吲唑结构式
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常用名 | 7-硝基吲唑 | 英文名 | 7-Nitroindazole |
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| CAS号 | 2942-42-9 | 分子量 | 163.133 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 211.2±23.0 °C at 760 mmHg | |
| 分子式 | C7H5N3O2 | 熔点 | 185-186°C | |
| MSDS | 中文版 美版 | 闪点 | 81.5±22.6 °C | |
| 符号 |
GHS06, GHS08 |
信号词 | Danger |
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Effects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of L-DOPA-induced dyskinesia in 6-OHDA-lesioned rats.
Neuropharmacology 89 , 87-99, (2014) It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry. The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance of NO in L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LI... |
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Tapentadol and nitric oxide synthase systems.
Behav. Pharmacol. 26(3) , 282-8, (2015) Tapentadol, a new analgesic drug with a dual mechanism of action (μ-opioid receptor agonism and norepinephrine reuptake inhibition), is indicated for the treatment of moderate to severe acute and chronic pain. In this paper, the possible additional involvemen... |
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Why Small Differences Matter: Elucidation of the Mechanisms Underlying the Transformation of 2OH- and 3OH-Carbamazepine in Contact with Sand Filter Material.
Environ. Sci. Technol. 49 , 10449-56, (2015) Carbamazepine (CBZ) is a worldwide used antiepileptic drug, which is metabolized to a large extent in the human body to several metabolites, including 10,11-dihydroxy-10,11-dihydrocarbamazepine (DiOHCBZ), 2-hydroxycarbamazepine (2OHCBZ), and 3-hydroxycarbamaz... |
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Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3(-/-) aphakia mice.
Neurobiol. Dis. 73 , 49-59, (2014) Nitric oxide (NO), a gaseous messenger molecule synthesized by nitric oxide synthase (NOS), plays a pivotal role in integrating dopamine transmission in the basal ganglia and has been implicated in the pathogenesis of Parkinson disease (PD). To study the role... |
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Cell-specific regulation of neuronal activity by endogenous production of nitric oxide.
Eur. J. Neurosci. 41(8) , 1013-24, (2015) Nitric oxide (NO) is a key regulator of neuronal excitability in the nervous system. While most studies have investigated its role as an intercellular messenger/modulator, less is known about potential physiological roles played by NO within NO-producing neur... |
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Selective Nitric Oxide Synthase Inhibitor 7-Nitroindazole Protects against Cocaine-Induced Oxidative Stress in Rat Brain.
Oxid. Med. Cell. Longev. 2015 , 157876, (2015) One of the mechanisms involved in the development of addiction, as well as in brain toxicity, is the oxidative stress. The aim of the current study was to investigate the effects of 7-nitroindazole (7-NI), a selective inhibitor of neuronal nitric oxide syntha... |
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Spontaneously hypertensive rats have more orexin neurons in the hypothalamus and enhanced orexinergic input and orexin 2 receptor-associated nitric oxide signalling in the rostral ventrolateral medulla.
Exp. Physiol. 100 , 993-1007, (2015) What is the central question of this study? Our previous study demonstrates that elevated orexin 2 receptor (OX2R) activity within the rostral ventrolateral medulla (RVLM) contributes to hypertension in spontaneously hypertensive rats (SHRs), and a lower OX2R... |
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Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.
Sci. Signal. 7(351) , ra106, (2014) Inflammation increases the abundance of inducible nitric oxide synthase (iNOS), leading to enhanced production of nitric oxide (NO), which can modify proteins by S-nitrosylation. Enhanced NO production increases the activities of the transcription factors p53... |
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S-Nitrosylation of proline-rich tyrosine kinase 2 involves its activation induced by oxygen-glucose deprivation.
Neurosci. Lett. 597 , 90-6, (2015) Previous studies have demonstrated that activation of proline-rich tyrosine kinase 2 (PYK2) in cerebral ischemia is involved in the modulation of N-methyl-d-aspartate-type (NMDA) glutamate receptor activity and Ca(2+) dynamics, resulting in ischemic neuron de... |
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Site-specific Effects of DUOX1-Related Peroxidase on Intercellular Apoptosis Signaling.
Anticancer Res. 35 , 5955-71, (2015) Intercellular apoptosis-inducing HOCl signaling is known as an interplay between superoxide anions/H₂O₂ of transformed target cells and dual oxidase 1 (DUOX1)-related peroxidase that is released from neighboring non-transformed or transformed effector cells. ... |