恶丙嗪
恶丙嗪结构式
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常用名 | 恶丙嗪 | 英文名 | OPIPRAMOL DIHYDROCHLORIDE |
|---|---|---|---|---|
| CAS号 | 909-39-7 | 分子量 | 436.41800 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C23H31Cl2N3O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
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Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression.
World J. Biol. Psychiatry 7(4) , 261-4, (2006) Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive experimental technique which has mostly been investigated in the treatment of mood disorders with possible efficacy in depression. Among its potential side effects, there have been some rep... |
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In vitro studies of DNA damage caused by tricyclic antidepressants: a role of peroxidase in the side effects of the drugs.
Chem. Res. Toxicol. 23(9) , 1497-503, (2010) Studies show that tricyclic antidepressants prescribed for migraines, anxiety, and child enuresis have numerous adverse effects in living cells. One of the undesired outcomes observed under treatment with these drugs is DNA damage. However, the mechanisms und... |
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Opipramol improves subjective quality of sleep the night prior to surgery: confirmatory testing of a double-blind, randomized clinical trial.
Neuropsychobiology 64(1) , 24-31, (2011) Due to its pharmacological properties, opipramol may be useful in the context of evening premedication in anaesthesiology. This trial examines whether quality of sleep the night prior to surgery can be improved by opipramol and whether this effect is dose dep... |
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Neuropharmacology of the anxiolytic drug opipramol, a sigma site ligand.
Pharmacopsychiatry 37 Suppl 3 , S189-97, (2004) Although opipramol is structurally related to imipramine, it does not represent a tricyclic antidepressant drug as it does not inhibit the neuronal uptake of norepinephrine and/or serotonin. Unlike imipramine it is a rather potent sigma ligand with modest sub... |
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[Opipramol in anxiety and somatoform disorders. Results of a controlled study].
Fortschr. Neurol. Psychiatr. 66 Suppl 1 , S21-4, (1998)
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[Opipramol in behavioral pharmacologic anxiety and depression models].
Fortschr. Neurol. Psychiatr. 66 Suppl 1 , S17-20, (1998)
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Determination of the chemical structure of potential organic impurities occurring in the drug substance opipramol.
Pharmazie 65(4) , 239-44, (2010) The tricyclic antipsychotic and antidepressant drug opipramol (opipramole) was examined with regard to the chemical structure of its organic impurities. Impurities were isolated from the technical product by chromatographic methods and their chemical structur... |
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[Pharmacokinetics and relative bioavailability of opipramol in the new INSIDON--sustained release preparation].
Fortschr. Neurol. Psychiatr. 66 Suppl 1 , S13-6, (1998)
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Bioavailability of opipramol from a film-coated tablet, a sugar-coated tablet and an aqueous solution in healthy volunteers.
Arzneimittelforschung 53(2) , 87-92, (2003) Opipramol (4-[3-(5H-dibenz[b,f]-azepine-5-yl)-propyl]-1-piperazine-ethanol dihydrochloride, CAS 315-72-0) is regarded as an anxiolytic compound with antidepressant properties, and it is one of the most frequently prescribed psychotropic drugs in Germany. In t... |
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Gastroprotective and antioxidant effects of opipramol on indomethacin-induced ulcers in rats.
Yakugaku Zasshi 129(7) , 861-9, (2009) Tricyclic antidepressants are particularly useful in the treatment of endogenous depression. Since the 1950s, tricyclic antidepressants (TCAs) have also been used for the treatment of gastric ulcer disease. Many TCAs have been evaluated for their antiulcer ef... |