3-氧代-N-[(3S)-2-氧代四氢呋喃-3-基]辛酰胺
![3-氧代-N-[(3S)-2-氧代四氢呋喃-3-基]辛酰胺结构式](https://image.chemsrc.com/caspic/496/147795-39-9.png)
3-氧代-N-[(3S)-2-氧代四氢呋喃-3-基]辛酰胺结构式
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常用名 | 3-氧代-N-[(3S)-2-氧代四氢呋喃-3-基]辛酰胺 | 英文名 | N-3-Oxo-octanoyl-L-homoserine lactone |
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| CAS号 | 147795-39-9 | 分子量 | 241.28 | |
| 密度 | 1.12g/cm3 | 沸点 | 490.1ºC at 760mmHg | |
| 分子式 | C12H19NO4 | 熔点 | 96-97 ºC (ethyl acetate ) | |
| MSDS | 中文版 美版 | 闪点 | 250.2ºC |
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Medicinal chemistry as a conduit for the modulation of quorum sensing.
J. Med. Chem. 53 , 7467-89, (2010)
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Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators.
Bioorg. Med. Chem. Lett. 18 , 5978-81, (2008) A focused library of N-aryl l-homoserine lactones was designed around known lactone leads and evaluated for antagonistic and agonistic activity against quorum-sensing receptors in Agrobacterium tumefaciens, Pseudomonas aeruginosa, and Vibrio fischeri. Several... |
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Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa.
Bioorg. Med. Chem. Lett. 18 , 3072-5, (2008) The transcription factor QscR is a regulator of quorum sensing in Pseudomonas aeruginosa and plays a role in controlling virulence in this prevalent opportunistic pathogen. This study outlines the discovery of a set of synthetic N-acylated homoserine lactones... |
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Influence and mechanism of N-(3-oxooxtanoyl)-L-homoserine lactone (C8-oxo-HSL) on biofilm behaviors at early stage.
J. Environ. Sci. (China) 24(12) , 2035-40, (2012) N-acyl-homoserines quenching, enzymatic quenching of bacterial quorum sensing, has recently applied to mitigate biofilm in membrane bioreactor. However, the effect of AHLs on the behavior of biofilm formation is still sparse. In this study, Pseudomonas aerugi... |
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Crystallization and preliminary X-ray diffraction studies of the transcriptional regulator TraR bound to its cofactor and to a specific DNA sequence.
Acta Crystallogr. D Biol. Crystallogr. 58(Pt 8) , 1362-4, (2002) TraR is an Agrobacterium tumefaciens transcriptional regulator which binds the pheromone N-3-oxooctanoyl-L-homoserine lactone (AAI) in response to the bacterial population density. The TraR-AAI complex dimerizes and interacts with a specific 18-base-pair DNA ... |
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A proteomic analysis of Arabidopsis thaliana seedling responses to 3-oxo-octanoyl-homoserine lactone, a bacterial quorum-sensing signal.
Biochem. Biophys. Res. Commun. 427(2) , 293-8, (2012) N-acyl-homoserine lactones (AHLs) are a class of bacterial quorum-sensing (QS) signals that are commonly used by Gram-negative bacteria for cell-to-cell communication. Recently, it has become evident that AHLs can regulate plant root growth and trigger plant ... |
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The Agrobacterium tumefaciens rnd homolog is required for TraR-mediated quorum-dependent activation of Ti plasmid tra gene expression.
J. Bacteriol. 183(13) , 3919-30, (2001) Conjugal transfer of Agrobacterium tumefaciens Ti plasmids is regulated by quorum sensing via TraR and its cognate autoinducer, N-(3-oxo-octanoyl)-L-homoserine lactone. We isolated four Tn5-induced mutants of A. tumefaciens C58 deficient in TraR-mediated acti... |
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Agrobacterium conjugation and gene regulation by N-acyl-L-homoserine lactones.
Nature 362(6419) , 446-8, (1993) Conjugal opines secreted by crown gall tumours induce strains of Agrobacterium tumefaciens that are donors of Ti plasmids to produce a diffusible conjugation factor. This enhances the conjugal transfer efficiency of the Ti plasmid in other strains of A. tumef... |
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TraI, a LuxI homologue, is responsible for production of conjugation factor, the Ti plasmid N-acylhomoserine lactone autoinducer.
Proc. Natl. Acad. Sci. U. S. A. 91(11) , 4639-43, (1994) Conjugal transfer of the nopaline-type Agrobacterium Ti plasmid pTiC58 is regulated by a transcriptional activator, TraR, and a diffusible signal molecule, conjugation factor (CF). CF is a member of a family of substituted homoserine lactones (HSLs) that act ... |
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Enzymatic synthesis of a quorum-sensing autoinducer through use of defined substrates.
Science 272(5268) , 1655-8, (1996) Many bacteria, including several pathogens of plants and humans, use a pheromone called an autoinducer to regulate gene expression in a cell density-dependent manner. Agrobacterium autoinducer [AAI, N-(3-oxo-octanoyl)-L-homoserine lactone] of A. tumefaciens i... |