萘啶酮酸
萘啶酮酸结构式
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常用名 | 萘啶酮酸 | 英文名 | Nalidixic acid |
|---|---|---|---|---|
| CAS号 | 389-08-2 | 分子量 | 232.235 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 413.1±45.0 °C at 760 mmHg | |
| 分子式 | C12H12N2O3 | 熔点 | 227-229 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 203.6±28.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Brucella abortus depends on pyruvate phosphate dikinase and malic enzyme but not on Fbp and GlpX fructose-1,6-bisphosphatases for full virulence in laboratory models.
J. Bacteriol. 196(16) , 3045-57, (2014) The brucellae are the etiological agents of brucellosis, a worldwide-distributed zoonosis. These bacteria are facultative intracellular parasites and thus are able to adjust their metabolism to the extra- and intracellular environments encountered during an i... |
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Recovery of Pseudomonas aeruginosa culturability following copper- and chlorine-induced stress.
FEMS Microbiol. Lett. 356(2) , 226-34, (2014) This study investigated how quickly cells of the opportunistic pathogen Pseudomonas aeruginosa recover culturability after exposure to two of the most common environmental stressors present in drinking water, free chlorine and copper ions. Viable but noncultu... |
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Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis.
J. Immunol. 195 , 5011-24, (2015) In the intestinal tract, IL-22 activates STAT3 to promote intestinal epithelial cell (IEC) homeostasis and tissue healing. The mechanism has remained obscure, but we demonstrate that IL-22 acts via tyrosine kinase 2 (Tyk2), a member of the Jak family. Using a... |
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Diversity and antimicrobial susceptibility profiling of staphylococci isolated from bovine mastitis cases and close human contacts.
J. Dairy Sci. 98 , 6256-69, (2015) The objectives of this study were to examine the diversity of Staphylococcus spp. recovered from bovine intramammary infections and humans working in close contact with the animals and to evaluate the susceptibility of the staphylococcal isolates to different... |
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Distribution and Molecular Characterization of Salmonella enterica Hypermutators in Retail Food in China.
J. Food Prot. 78 , 1481-7, (2015) Hypermutable pathogens can easily acquire mutation opportunities, as well as antimicrobial resistance, and are tremendous hazards to food safety and public health. In this study, a total of 96 (7.6%) hypermutators were identified from 1,264 Salmonella isolate... |
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Characterization of TolC efflux pump proteins from Pasteurella multocida.
Antimicrob. Agents Chemother. 52 , 4166-71, (2008) Two TolC homologs, PM0527 and PM1980, were identified for Pasteurella multocida. A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold). A pm1980 mutant showed increased suscept... |
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RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine.
Antimicrob. Agents Chemother. 52 , 3604-11, (2008) Salmonella enterica serovar Typhimurium SL1344, in which efflux pump genes (acrB, acrD, acrF, tolC) or regulatory genes thereof (marA, soxS, ramA) were inactivated, was grown in the presence of 240 antimicrobial and nonantimicrobial agents in the Biolog Pheno... |
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Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate.
Antimicrob. Agents Chemother. 51 , 3247-53, (2007) Enterobacter cloacae is an emerging clinical pathogen that may be responsible for nosocomial infections. Management of these infections is often difficult, owing to the high frequency of strains that are resistant to disinfectants and antimicrobial agents in ... |
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Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli.
Antimicrob. Agents Chemother. 52 , 3052-60, (2008) Active efflux of antimicrobial agents is one of the most important adapted strategies that bacteria use to defend against antimicrobial factors that are present in their environment. The NorM protein of Neisseria gonorrhoeae and the YdhE protein of Escherichi... |
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New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate.
Antimicrob. Agents Chemother. 51 , 3354-60, (2007) Plasmid-mediated Qnr and AAC(6')-Ib-cr have been recognized as new molecular mechanisms affecting fluoroquinolone (FQ) resistance. C316, an Escherichia coli strain demonstrating resistance to various FQs, was isolated in Japan. Resistance to FQs was augmented... |