α-生育酚醋酸酯
α-生育酚醋酸酯结构式
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常用名 | α-生育酚醋酸酯 | 英文名 | alpha-Tocopherol acetate |
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| CAS号 | 58-95-7 | 分子量 | 472.743 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 184 ºC | |
| 分子式 | C31H52O3 | 熔点 | 28 ºC | |
| MSDS | 中文版 美版 | 闪点 | 235.6±24.7 °C |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Phytantriol-based in situ liquid crystals with long-term release for intra-articular administration.
AAPS PharmSciTech 16 , 846-54, (2015) The purpose of this study was to develop an injectable in situ liquid crystal formulation for intra-articular (IA) administration, and in situ forming a viscous liquid crystalline gel with long-term release of sinomenine hydrochloride (SMH) upon water absorpt... |
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Microbeads: a novel multiparticulate drug delivery technology for increasing the solubility and dissolution of celecoxib.
Pharm. Dev. Technol. 20(2) , 211-8, (2015) The purpose of this study was to develop a novel multipaticulate drug delivery technology suitable for the delivery of pre-solubilized celecoxib to the gastrointestinal tract and more specifically to the colon. The solubility of celecoxib in a range of oils, ... |
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Long-term alpha-tocopherol supplements may improve mental development in extremely low birthweight infants.
Acta Paediatr. 104(2) , e82-9, (2015) Methods to improve the mental development of extremely low birthweight (ELBW) children are currently lacking. We assessed the effects of long-term supplementation of alpha-tocopherol on the neurological development of 259 school-aged ELBW children.Extremely l... |
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Sodium dl-α-tocopheryl-6-O-phosphate inhibits PGE₂ production in keratinocytes induced by UVB, IL-1β and peroxidants.
Bioorg. Med. Chem. 19 , 6348-55, (2011) The water-soluble vitamin E derivative, sodium dl-α-tocopheryl-6-O-phosphate (1), exhibits protective effects against skin damage. As reported herein, we investigated the actions of 1 on the formation of the inflammatory mediator, prostaglandin E(2) (PGE(2)),... |
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Synthesis of some N-substituted nitroimidazole derivatives as potential antioxidant and antifungal agents.
Eur. J. Med. Chem. 44 , 645-52, (2009) Some new nitroimidazole derivatives have been synthesized by treating 4,5-dinitro- and 2-methyl-4,5-dinitroimidazoles with epoxypropane, epichlorohydrin or phenacyl bromide in alkylation reactions. The nitro group in N-substituted 4,5-dinitro- and 2-methyl-4,... |
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In vivo ruminal degradation characteristics and apparent digestibility of low-quality prairie hay for steers consuming monensin and Optimase.
J. Anim. Sci. 93 , 3941-9, (2015) Seven ruminally cannulated crossbred steers (BW = 720 ± 62 kg) were used in a randomized crossover design (4 periods, each 18 d) to evaluate in vivo rumen characteristics and apparent digestibility of steers consuming low-quality prairie hay and 1 of 4 isonit... |
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Immune activation reduces sperm quality in the great tit.
PLoS ONE 6 , e22221, (2011) Mounting an immune response against pathogens incurs costs to organisms by its effects on important life-history traits, such as reproductive investment and survival. As shown recently, immune activation produces large amounts of reactive species and is sugge... |
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Comparison of the photochemical behaviors of α-tocopherol and its acetate in organic and aqueous micellar solutions.
J. Phys. Chem. A 115 , 8242-8247, (2011) Photoionization is known to take place when α-tocopherol (TOH) is excited to the S(1) state in a polar medium. It has been previously suggested that TO(•) is formed only as a result of proton release by TOH(•+), a process that is expected to occur, in a proti... |
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Effect of vitamin E on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-κB after treatment with phenobarbital.
Food Chem. Toxicol. 49 , 2706-2709, (2011) Phenobarbital (PB) is an efficacious and well-studied hepatic tumor promoting agent. Nuclear factor-κB (NF-κB) is a transcription factor activated by reactive oxygen and is involved in cell proliferation and apoptosis. We previously found that PB activates NF... |