米托坦
米托坦结构式
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常用名 | 米托坦 | 英文名 | Mitotane |
|---|---|---|---|---|
| CAS号 | 53-19-0 | 分子量 | 320.041 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 398.9±37.0 °C at 760 mmHg | |
| 分子式 | C14H10Cl4 | 熔点 | 77-78 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 194.2±23.9 °C | |
| 符号 |
GHS08 |
信号词 | Warning |
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A simple method for the determination of organochlorine pollutants and the enantiomers in oil seeds based on matrix solid-phase dispersion.
Food Chem. 194 , 319-24, (2015) A simple, rapid and effective method was developed based on matrix solid-phase dispersion (MSPD) for the determination of organochlorine pollutants including sixteen organochlorine pesticides (OCPs) and seven polychlorinated biphenyls (PCBs) in oil seeds (pea... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Distribution and uptake pathways of organochlorine pesticides in greenhouse and conventional vegetables.
Sci. Total Environ. 505 , 1142-7, (2014) The application of greenhouse vegetable cultivation has dramatically expanded worldwide during the last several decades. However, little information is available on the distribution and uptake of pesticides in greenhouse vegetables. To bridge this knowledge g... |
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Simultaneous analysis of polychlorinated biphenyls and organochlorine pesticides in seawater samples by membrane-assisted solvent extraction combined with gas chromatography-electron capture detector and gas chromatography-tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 972 , 58-64, (2014) A highly efficient and environment-friendly membrane-assisted solvent extraction system combined with gas chromatography-electron capture detector was applied in the simultaneous determination of 17 polychlorinated biphenyls and organochlorine pesticides in s... |
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Rapid control of severe neoplastic hypercortisolism with metyrapone and ketoconazole.
Eur. J. Endocrinol. 172(4) , 473-81, (2015) Severe Cushing's syndrome elicited by ectopic ACTH syndrome (EAS) or adrenal carcinoma (ACC) can threaten life in the short term. The effectiveness of oral administration of the inhibitors of steroidogenesis ketoconazole and metyrapone in this situation is po... |
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Diagnosis, treatment and outcome of adrenocortical cancer.
Br. J. Surg. 102(4) , 291-306, (2015) Adrenocortical cancer (ACC) is a rare disease with a dismal prognosis. The majority of patients are diagnosed with advanced disease and raise difficult management challenges.All references identified in PubMed, published between 2004 and 2014, using the keywo... |
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QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.
Eur. J. Med. Chem. 45 , 1639-47, (2010) Three different splits into the subtraining set (n = 22), the set of calibration (n = 21), and the test set (n = 12) of 55 antineoplastic agents have been examined. By the correlation balance of SMILES-based optimal descriptors quite satisfactory models for t... |
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Advances in medical therapies for Cushing's syndrome.
Discov. Med. 13(69) , 171-9, (2012) Cushing's syndrome (CS) is a heterogeneous disorder of diverse etiologies, leading to cortisol excess. Endogenous CS is caused by tumors secreting adrenocorticotropin (ACTH) (either eutopically or ectopically), cortisol, or very rarely corticotropin-releasing... |