葫芦素 E
葫芦素 E结构式
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常用名 | 葫芦素 E | 英文名 | Cucurbitacin E |
|---|---|---|---|---|
| CAS号 | 18444-66-1 | 分子量 | 556.687 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 712.6±60.0 °C at 760 mmHg | |
| 分子式 | C32H44O8 | 熔点 | 228-234ºC | |
| MSDS | 中文版 美版 | 闪点 | 224.4±26.4 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Interaction of cucurbitacins with human serum albumin: Thermodynamic characteristics and influence on the binding of site specific ligands.
J. Photochem. Photobiol. B, Biol. 95(3) , 189-95, (2009) Cucurbitacins (Cuc) are cytotoxic oxygenated triterpenes. Their binding to albumin may control their diffusion and consequently their biological effects. The specific binding site of Cuc to albumin is important to be defined as it could determine some of the ... |
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Quantitative determination of cucurbitacin E and cucurbitacin I in homoeopathic mother tincture of Gratiola officinalis L. by HPLC.
Pharmazie 63(12) , 851-3, (2008) "Hedgehyssop" Gratiola officinalis L. (Scrophulariaceae) is found as an ingredient in homeopathic remedies. Among the active compounds found in G. officinalis, the cucurbitacines constitute a group of triterpenoid substances which are well-known for their bit... |
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The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2alpha in leukemia cells.
Anticancer Drugs 21(4) , 389-400, (2010) The antiproliferative and apoptotic effects of cucurbitacin E, a natural product isolated from Cucurbitaceae, were determined in human leukemia HL-60 cells. Cucurbitacin E at low concentrations (3-50 nmol/l) inhibited the growth of HL-60 cells, which was asso... |
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Effect of cucurbitacins on bilirubin-albumin binding in human plasma.
Life Sci. 80(6) , 579-85, (2007) The aim of this study is to investigate the effect of three cucurbitacins (Cuc) E, D and I on the bilirubin-albumin binding, both in human serum albumin (HSA) and in plasma. Bilirubin-HSA solution and plasma free of cucurbitacins were prepared as well as othe... |
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Immunomodulatory activity of cucurbitacin E isolated from Ecballium elaterium.
Fitoterapia 76(5) , 439-41, (2005) The immunomodulatory effect of cucurbitacin E, extracted from Ecballium elaterium, was tested on peripheral human lymphocytes. These lymphocytes were co-cultured with cancer cells and an interesting lymphocyte-mediated cytotoxicity was observed. |
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Growth inhibitory effect of Cucurbitacin E on breast cancer cells.
Int. J. Clin. Exp. Pathol. 6(9) , 1799-805, (2013) Due its inhibitory effects on chemical carcinogenesis and inflammation, Cucurbitacins have been proposed as an effective agent for the prevention or treatment of human cancers. In this study, we aimed to explore the effect of Cucurbitacin E (CuE) on human bre... |
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Stability of cucurbitacin E in human plasma: chemical hydrolysis and role of plasma esterases.
Biopharm. Drug Dispos. 30(7) , 389-97, (2009) It was shown previously that the anticancerous cytotoxic oxygenated triterpenes, cucurbitacin E (Cuc E) and its deacetylated form, cucurbitacin I (Cuc I), interacted differently with human serum albumin. In this study, the biochemical stability of Cuc E was i... |
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Morierinin: a new cytotoxic cucurbitacin from the leaves of Morierina montana Vieill.
Nat. Prod. Res. 17(4) , 229-33, (2003) An extract of the leaves of Morierina montana collected in New Caledonia was found to be cytotoxic for KB cells. A bioassay-guided fractionation procedure led to the isolation of a series of cucurbitacins of which one, morierinin (1), is new. The isolation an... |
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Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad.
Molecules 20 , 18001-15, (2015) Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly N... |
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[Inhibitory effect of cucurbitacin E on the proliferation of ovarian cancer cells and its mechanism].
Chin. J. Cancer 29(1) , 20-4, (2010) There are various biological activities of cucurbitacin E (CuE), including antitumor effect, anti-chemical carcino-genesis, liver protection, and enhancement of the immunity, and so on. This study was to investigate the effect of CuE on proliferation inhibiti... |