苯甲酸利扎曲坦
苯甲酸利扎曲坦结构式
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常用名 | 苯甲酸利扎曲坦 | 英文名 | Rizatriptan benzoate |
|---|---|---|---|---|
| CAS号 | 145202-66-0 | 分子量 | 391.466 | |
| 密度 | 1.21g/cm3 | 沸点 | 504.8ºC at 760mmHg | |
| 分子式 | C22H25N5O2 | 熔点 | 178-180°C | |
| MSDS | 中文版 美版 | 闪点 | 259.1ºC | |
| 符号 |
GHS08 |
信号词 | Danger |
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Evolution of paediatric off-label use after new significant medicines become available for adults: a study on triptans in Finnish children 1994-2007.
Br. J. Clin. Pharmacol. 71(6) , 929-35, (2011) • Off-label use in children is widespread. New medicines lack marketing authorization for paediatric use, even when they represent significant therapeutic advantages and are intended for treatment of conditions common in children. • Until now no information e... |
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An approach for rapid development of nasal delivery of analgesics--identification of relevant features, in vitro screening and in vivo verification.
Int. J. Pharm. 420(1) , 43-50, (2011) Drug delivery via the nasal route is gaining increasing interest over the last two decades as an alternative to oral or parenteral drug administration. In the current study an approach for rapid identification of relevant features, screening and in vivo verif... |
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Efficacy and tolerability of rizatriptan for the treatment of acute migraine in sumatriptan non-responders.
Cephalalgia 31(7) , 786-96, (2011) The study was carried out to assess the efficacy and tolerability of rizatriptan orally disintegrating tablet (ODT) for treating acute migraine in patients who are non-responders to sumatriptan.Many migraineurs report dissatisfaction with sumatriptan efficacy... |
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Rizatriptan in migraineurs with unilateral cranial autonomic symptoms: a double-blind trial.
J. Headache Pain 13(5) , 407-14, (2012) The objective and background is to confirm in a double-blind, placebo-controlled study the high triptan response rates we had previously reported in an open study in migraine patients with unilateral cranial autonomic symptoms. In this randomized, double-blin... |
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Brain apparent water diffusion coefficient magnetic resonance image during a prolonged visual aura.
Headache 50(6) , 1045-9, (2010) Reversible changes in brain magnetic resonance imaging (MRI) weighted in diffusion-weighted images (DWI) and apparent water diffusion coefficient (ADC) maps have been reported in acute stroke, epilepsy, eclampsia, and hypoglycemia, but they are contradictory ... |
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Implication of free cholesterol in LC-MS response enhancement.
Bioanalysis 4(10) , 1163-73, (2012) In the context of matrix effects in bioanalytical LC-MS/MS, a speculative link between free cholesterol, the recoveries of the compound from three common extraction procedures, and response enhancement was qualitatively investigated.Injections on-column of ch... |
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Nociceptive behaviors were induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats and reduced by morphine and rizatriptan benzoate.
Brain Res. 1368 , 151-8, (2011) The trigeminovascular nociception induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in anesthetized animals has been widely used as a model for investigation of the pathophysiology of vascular headache such as migrain... |
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Efficacy and tolerability of rizatriptan 10 mg compared with sumatriptan 100 mg: an evidence-based analysis.
Expert Rev. Neurother. 10(4) , 499-506, (2010) Acute migraine attacks have a strong impact on quality of life and require immediate therapeutic intervention to achieve rapid pain relief. The introduction of triptans into the market in 1993 has increased the therapeutic options in migraine patients conside... |
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The Fos expression in rat brain following electrical stimulation of dura mater surrounding the superior sagittal sinus changed with the pre-treatment of rizatriptan benzoate.
Brain Res. 1367 , 340-6, (2011) Fos expression in the brain was systematically investigated by means of immunohistochemical staining after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious rats. Fos-like immunoreactive neurons are distributed main... |
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Efficacy of parecoxib, sumatriptan, and rizatriptan in the treatment of acute migraine attacks.
Clin. Neuropharmacol. 34(6) , 206-9, (2011) Triptans and analgetic nonsteroidal inflammatory drugs reduce acute pain syndromes in migraine. A further treatment option for an acute headache attack in patients with migraine may be the application of cyclooxygenase-2-specific inhibitors, as they have anti... |