嘧啶
嘧啶结构式
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常用名 | 嘧啶 | 英文名 | Pyrimidine |
|---|---|---|---|---|
| CAS号 | 289-95-2 | 分子量 | 80.088 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 122.4±9.0 °C at 760 mmHg | |
| 分子式 | C4H4N2 | 熔点 | 19-22 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 31.1±0.0 °C | |
| 符号 |
GHS02 |
信号词 | Warning |
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Assessing the metabolic impact of nitrogen availability using a compartmentalized maize leaf genome-scale model.
Plant Physiol. 166(3) , 1659-74, (2014) Maize (Zea mays) is an important C4 plant due to its widespread use as a cereal and energy crop. A second-generation genome-scale metabolic model for the maize leaf was created to capture C4 carbon fixation and investigate nitrogen (N) assimilation by modelin... |
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Orthovanadate-Induced Vasoconstriction of Rat Mesenteric Arteries Is Mediated by Rho Kinase-Dependent Inhibition of Myosin Light Chain Phosphatase.
Biol. Pharm. Bull. 38 , 1809-16, (2015) Orthovanadate (OVA), a protein tyrosine phosphatase inhibitor, induces vasoconstriction in a Rho kinase-dependent manner. The aim of this study was to determine the mechanism underlying OVA-induced vasoconstriction of rat mesenteric arteries. OVA-induced cons... |
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Cetuximab-induced insulin-like growth factor receptor I activation mediates cetuximab resistance in gastric cancer cells.
Mol. Med. Report. 11 , 4547-54, (2015) Epidermal growth factor receptor (EGFR) and insulin‑like growth factor receptor‑I (IGF‑IR) are frequently overexpressed in gastric cancer cells. However, these cells are resistant to the anti‑EGFR monoclonal antibody cetuximab. The aim of the present study wa... |
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Pyrimidine homeostasis is accomplished by directed overflow metabolism.
Nature 500(7461) , 237-41, (2013) Cellular metabolism converts available nutrients into usable energy and biomass precursors. The process is regulated to facilitate efficient nutrient use and metabolic homeostasis. Feedback inhibition of the first committed step of a pathway by its final prod... |
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Inference of Network Dynamics and Metabolic Interactions in the Gut Microbiome.
PLoS Comput. Biol. 11 , e1004338, (2015) We present a novel methodology to construct a Boolean dynamic model from time series metagenomic information and integrate this modeling with genome-scale metabolic network reconstructions to identify metabolic underpinnings for microbial interactions. We app... |
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Preparation of heparan sulfate-like polysaccharide and application in stem cell chondrogenic differentiation.
Carbohydr. Res. 401 , 32-8, (2014) Heparan sulfate is a component of the extracellular matrix (ECM) that modulates individual development and cell growth through its interaction with growth factors. Structurally, heparan sulfate consists of repeating linear sulfated poly-anionic disaccharide s... |
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A facile synthesis of new monoazo disperse dyes derived from 4-hydroxyphenylazopyrazole-5-amines: evaluation of microwave assisted dyeing behavior.
Molecules 17(12) , 13891-909, (2012) A series of new monoazo disperse dyes containing pyrazolopyrimidine moieties was synthesized by coupling malononitrile or 3-aminocrotononitrile with 4-hydroxy- benzenediazonium chloride. Treatment of the resulting products with hydrazine hydrate yields the co... |
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Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells.
PLoS ONE 9(12) , e114019, (2014) Nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in cellular bioenergetics. It is responsible for converting nicotinamide to nicotinamide adenine dinucleotide, an essential molecule in cellular metabolism. NAMPT has been extensively stud... |
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Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells.
Drug Des. Devel. Ther. 9 , 349-417, (2015) Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells usi... |
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Inhibition of TRPM7 Attenuates Rat Aortic Smooth Muscle Cell Proliferation Induced by Angiotensin II: Role of Genistein.
J. Cardiovasc. Pharmacol. 66 , 16-24, (2015) Transient receptor potential melastatin 7 (TRPM7) is a Ca, Mg permeable nonselective cation channel of the TRP channel superfamily and plays an important role in cell growth and proliferation. Compounds that alter the activity and expression of the channel pr... |