吡啶-2,5-二羧酸
吡啶-2,5-二羧酸结构式
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常用名 | 吡啶-2,5-二羧酸 | 英文名 | 2,5-Pyridinedicarboxylic acid |
|---|---|---|---|---|
| CAS号 | 100-26-5 | 分子量 | 167.12 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 441.1±30.0 °C at 760 mmHg | |
| 分子式 | C7H5NO4 | 熔点 | 242-247 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 220.5±24.6 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metallop... |
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Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila.
Antimicrob. Agents Chemother. 51 , 2136-42, (2007) Various inhibitors of metallo-beta-lactamases have been reported; however, none are effective for all subgroups. Those that have been found to inhibit the enzymes of subclass B2 (catalytically active with one zinc) either contain a thiol (and show less inhibi... |
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Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
J. Med. Chem. 51 , 7053-6, (2008) The dynamic methylation of histone lysyl residues plays an important role in biology by regulating transcription, maintaining genomic integrity, and by contributing to epigenetic effects. Here we describe a variety of inhibitor scaffolds that inhibit the huma... |