左啡诺
左啡诺结构式
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常用名 | 左啡诺 | 英文名 | tilidine hydrochloride hemihydrate |
|---|---|---|---|---|
| CAS号 | 27107-79-5 | 分子量 | 327.84600 | |
| 密度 | N/A | 沸点 | 354.2ºC at 760mmHg | |
| 分子式 | C17H26ClNO3 | 熔点 | 149-152?C | |
| MSDS | N/A | 闪点 | 114ºC | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Development and validation of a sensitive UPLC-MS/MS method for the analysis of narcotic analgesics in urine and whole blood in forensic context.
Forensic Sci. Int. 215(1-3) , 136-45, (2012) Narcotic analgesics are widely (ab) used and sometimes only occur in low concentrations in biological samples. Therefore, a highly sensitive liquid chromatography tandem mass spectrometry method was developed for simultaneous analysis of 9 narcotic analgesics... |
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An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites.
J. Mass Spectrom. 41(5) , 633-40, (2006) A fully validated liquid chromatographic procedure coupled with electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) is presented for quantitative determination of the opioids buprenorphine, codeine, fentanyl, hydromorphone, methadone, morphine, ox... |
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Pharmacokinetics of tilidine and naloxone in patients with severe hepatic impairment.
Arzneimittelforschung 57(2) , 106-11, (2007) The objective of the present study was to evaluate the pharmacokinetics of tilidine (CAS 20380-58-9), naloxone (CAS 465-65-6) and tilidine metabolites after administration of a single oral dose of a solution containing 100 mg tilidine hydrochloride and 8 mg n... |
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Structural elucidation and quantification of phenolic conjugates present in human urine after tea intake.
Anal. Chem. 84(16) , 7263-71, (2012) In dietary polyphenol exposure studies, annotation and identification of urinary metabolites present at low (micromolar) concentrations are major obstacles. To determine the biological activity of specific components, it is necessary to have the correct struc... |
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Aplastic right coronary artery and left coronary artery with a separate origin of the circumflex branch in a 31-year-old woman.
Forensic Sci. Int. 173(2-3) , 178-81, (2007) Singular coronary arteries are a rare feature appearing in approximately 0.05% of the population. The clinical relevance of those anomalies varies a lot. The wide range of descriptions reaches from asymptomatic cases to sudden cardiac death. This will be disc... |
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Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine.
Br. J. Clin. Pharmacol. 74(5) , 854-63, (2012) The analgesic activity of tilidine is mediated by its active metabolite, nortilidine, which easily penetrates the blood-brain barrier and binds to the µ-opioid receptor as a potent agonist. Tilidine undergoes an extensive first-pass metabolism, which has been... |
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In vitro identification of the cytochrome P450 isozymes involved in the N-demethylation of the active opioid metabolite nortilidine to bisnortilidine.
Naunyn Schmiedebergs Arch. Pharmacol. 385(6) , 633-9, (2012) Tilidine exhibits the highest consumption of opioids in Germany. The prodrug is hepatically metabolised in a sequential N-demethylation reaction. Its primary metabolite nortilidine is a selective μ-opioid receptor agonist which can penetrate the blood-brain b... |
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Rapid quantification of tilidine, nortilidine, and bisnortilidine in urine by automated online SPE-LC-MS/MS.
Anal. Bioanal. Chem 400(1) , 17-23, (2011) The opioid tilidine is a prodrug which is hepatically metabolized to active nortilidine and bisnortilidine. Due to the increasing abuse of tilidine by drug users and the lack of a specific immunoassay, we developed an analytical method for the quantification ... |
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Inhibition of the active principle of the weak opioid tilidine by the triazole antifungal voriconazole.
Br. J. Clin. Pharmacol. 68(5) , 712-20, (2009) To investigate in vivo the influence of the potent CYP2C19 and CYP3A4 inhibitor voriconazole on the pharmacokinetics and analgesic effects of tilidine.Sixteen healthy volunteers received voriconazole (400 mg) or placebo together with a single oral dose of til... |
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In vitro metabolism of the opioid tilidine and interaction of tilidine and nortilidine with CYP3A4, CYP2C19, and CYP2D6.
Naunyn Schmiedebergs Arch. Pharmacol. 378(3) , 275-82, (2008) Tilidine is one of the most widely used narcotics in Germany and Belgium. The compound's active metabolite nortilidine easily penetrates the blood-brain barrier and activates the mu-opioid receptor. Thus far, the enzymes involved in tilidine metabolism are un... |