盐酸小檗胺
盐酸小檗胺结构式
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常用名 | 盐酸小檗胺 | 英文名 | Berbamine hydrochloride |
|---|---|---|---|---|
| CAS号 | 6078-17-7 | 分子量 | 681.65 | |
| 密度 | N/A | 沸点 | 744.4ºC at 760 mmHg | |
| 分子式 | C37H42Cl2N2O6 | 熔点 | 250-253ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 404ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Flavonols, alkaloids, and antioxidant capacity of edible wild berberis species from patagonia.
J. Agric. Food Chem. 62(51) , 12407-17, (2014) There are 20 species of the Berberidaceae family described in Chile, whose fruits are edible and show high anthocyanin and hydroxycinnamic acid levels. Berberis microphylla G. Forst, commonly known as calafate, is the most extensively distributed. Flavonols a... |
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Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells.
Acta Pharmacol. Sin. 30(12) , 1659-65, (2009) We sought to investigate the effect of berbamine on the growth of human multiple myeloma cell line KM3 and elucidate the mechanism of its action.MTT assay was used to determine the inhibitory effect of berbamine alone or combined with chemotherapeutic drugs. ... |
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Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice.
J. Asian Nat. Prod. Res. 11(3) , 219-28, (2009) Berbamine, a natural compound from the plant Berberis amurensis, is a traditional Chinese medicine mainly used in stimulating normal hematopoiesis in clinic. Our previous studies demonstrated that berbamine has anti-leukemia activity. In this study, we invest... |
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Berbamine selectively induces apoptosis of human acute promyelocytic leukemia cells via survivin-mediated pathway.
Chin. Med. J. 120(9) , 802-6, (2007) Currently, resistance and relapse are still major problems in acute promyelocytic leukemia (APL) cases. Thus, new agents that override the resistance are crucial to the development of curative therapies for APL. In this study, we investigated the effects of b... |
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Synthesis of berbamine acetyl glycosides and evaluation of antitumor activity.
Eur. J. Med. Chem. 54 , 867-72, (2012) A series of berbamine glycosides was designed, synthesized and evaluated as a new class of antitumor agents. An efficient glycosylation route was developed for berbamide derivatives. The newly synthesized glycosides were evaluated for their cytotoxic activity... |
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The interaction of telomere DNA G-quadruplex with three bis-benzyltetrahydroisoquinoline alkaloids.
Nucleic Acid Ther. 21(6) , 415-22, (2011) Telomeres are important multifunctional nucleoprotein structures located at the ends of eukaryotic chromosomes. Telomerase regulates telomere elongation, and its activity is associated with tumorigenesis. Because the activity of telomerase can be inhibited by... |
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Berbamine increases myocardial contractility via a Ca2+-independent mechanism.
J. Cardiovasc. Pharmacol. 58(1) , 40-8, (2011) Berbamine (BM), a natural compound derived from Berberis vulgaris L, has been reported to inhibit cardiac contractile function at higher concentrations. Here, we report that BM had concentration-dependent biphasic effects on myocardial contraction in Langendo... |
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The antiproliferation effect of berbamine on k562 resistant cells by inhibiting NF-kappaB pathway.
Anat. Rec. (Hoboken.) 292(7) , 945-50, (2009) Imatinib mesylate is effective against Ph chromosome-positive leukemia; however, resistance has been reported. High expression of bcr-abl in mRNA and protein levels, and other alterations were found in patients who experienced imatinib treatment failures and ... |
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Berbamine inhibits proliferation and induces apoptosis of KU812 cells by increasing Smad3 activity.
J. Zhejiang Univ. Sci. B 12(7) , 568-74, (2011) The cytotoxic effect of berbamine on chronic myeloid leukemia (CML) cell line KU812 was evaluated, and the mechanisms of its action were explored.The effect of berbamine on the KU812 cell growth was determined by methyl thiazolyl tetrazolium (MTT) assay. Flow... |
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Berbamine overcomes imatinib-induced neutropenia and permits cytogenetic responses in Chinese patients with chronic-phase chronic myeloid leukemia.
Int. J. Hematol. 94(2) , 156-62, (2011) During imatinib therapy, many patients with chronic myeloid leukemia (CML) develop severe neutropenia, leading to treatment interruptions, and potentially compromising response to imatinib. Berbamine (a bisbenzylisoquinoline alkaloid) has been widely used in ... |