NU6027
NU6027结构式
|
常用名 | NU6027 | 英文名 | NU6027 |
|---|---|---|---|---|
| CAS号 | 220036-08-8 | 分子量 | 251.285 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 549.2±60.0 °C at 760 mmHg | |
| 分子式 | C11H17N5O2 | 熔点 | 252.5-253.7 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 286.0±32.9 °C |
|
Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells.
PLoS ONE 8 , e57098, (2013) Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repair. XRCC1 is a critical enzyme in single strand break repair... |
|
|
Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines.
Br. J. Cancer 105 , 372-81, (2011) The ataxia telangiectasia mutated and Rad3-related kinase (ATR) has a key role in the signalling of stalled replication forks and DNA damage to cell cycle checkpoints and DNA repair. It has long been recognised as an important target for cancer therapy but in... |
|
|
Kinetically-defined component actions in gene repression.
PLoS Comput. Biol. 11(3) , e1004122, (2015) Gene repression by transcription factors, and glucocorticoid receptors (GR) in particular, is a critical, but poorly understood, physiological response. Among the many unresolved questions is the difference between GR regulated induction and repression, and w... |
|
|
HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability.
Nucleic Acids Res. 42(21) , 13074-81, (2014) CLASPIN is an essential mediator in the DNA replication checkpoint, responsible for ATR (ataxia telangiectasia and Rad3-related protein)-dependent activation of CHK1 (checkpoint kinase 1). Here we found a dynamic signaling pathway that regulates CLASPIN turn ... |