色氨
色氨结构式
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常用名 | 色氨 | 英文名 | 2-(1h-indol-3-yl)ethanaminhydrochlorid |
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| CAS号 | 343-94-2 | 分子量 | 196.677 | |
| 密度 | 1.157g/cm3 | 沸点 | 378.8ºC at 760mmHg | |
| 分子式 | C10H13ClN2 | 熔点 | 253-255 °C(lit.) | |
| MSDS | 美版 | 闪点 | 187.7ºC |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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New procedure of selected biogenic amines determination in wine samples by HPLC.
Anal. Chim. Acta 834 , 58-66, (2014) A new procedure for determination of biogenic amines (BA): histamine, phenethylamine, tyramine and tryptamine, based on the derivatization reaction with 2-chloro-1,3-dinitro-5-(trifluoromethyl)-benzene (CNBF), is proposed. The amines derivatives with CNBF wer... |
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Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline.
Chem. Commun. (Camb.) 49(19) , 1954-6, (2013) Starting from (S)-tryptophanol, a formal synthesis of ent-rhynchophylline and ent-isorhynchophylline, involving stereoselective cyclocondensation, spirocyclization, and alkylation reactions, and the final adjustment of the oxidation level at the oxindole and ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Effect of Novel Starter Culture on Reduction of Biogenic Amines, Quality Improvement, and Sensory Properties of Doenjang, a Traditional Korean Soybean Fermented Sauce Variety.
J. Food Sci. 80 , M1794-803, (2015) To select appropriate microorganisms as starter cultures for the reliable and reproducible fermentation of soybean fermented products of Korean Doenjang, various ratios of fungi (Aspergillus oryzae J, Mucor racemosus 15, M. racemosus 42) combined with Bacillu... |
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Automated derivatization and fluorimetric determination of biogenic amines in milk by zone fluidics coupled to liquid chromatography.
J. Chromatogr. A. 1356 , 272-6, (2014) A novel zone-fluidics/high pressure liquid chromatographic (ZF-HPLC) method is described for the simultaneous determination of six biogenic monoamines, in the presence of hexylamine as internal standard. Automated on-line derivatization of the analytes with n... |
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Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine.
Br. J. Pharmacol. 165(7) , 2191-202, (2012) Tryptamine increases blood pressure by vasoconstriction, but little is known about its actions on the mesentery, in particular the resistance arteries. Tryptamine interacts with trace amine-associated receptors (TAARs) and because of its structural similarity... |
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Indium/TFA-catalyzed synthesis of tetracyclic [6,5,5,6] indole ring, via a tandem cycloannulation of β-oxodithioester with tryptamine.
Org. Lett. 15(8) , 1974-7, (2013) The cycloannulation of β-oxodithioesters and tryptamine in dichloromethane in the presence of a catalytic amount of InCl3 and TFA gave the novel 5-aryl/heteroaryl 2a(1),9b-dihydro-1H-2a,5a-diaza-cyclopenta[jk]fluorene-3(2H)-thiones in moderate to good yields.... |
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Determinants involved in subtype-specific functions of rat trace amine-associated receptors 1 and 4.
Br. J. Pharmacol. 168(5) , 1266-78, (2013) The trace amine-associated receptor (Taar) family displays high species- and subtype-specific pharmacology. Several trace amines such as β-phenylethylamine (β-PEA), p-tyramine and tryptamine are agonists at TA(1) but poorly activate rat and mouse Taar4.Using ... |
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Tolerance and cross-tolerance to head twitch behavior elicited by phenethylamine- and tryptamine-derived hallucinogens in mice.
J. Pharmacol. Exp. Ther. 351(3) , 485-91, (2014) The serotonin 5-hydroxytryptamine 2A (5-HT2A) receptor is a potential therapeutic target to a host of neuropsychiatric conditions, but agonist actions at this site are linked to abuse-related hallucinogenic effects that may limit therapeutic efficacy of chron... |