[PYR]HWSYGLRPG-OH
![[PYR]HWSYGLRPG-OH结构式](https://image.chemsrc.com/caspic/264/35263-73-1.png)
[PYR]HWSYGLRPG-OH结构式
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常用名 | [PYR]HWSYGLRPG-OH | 英文名 | LHRH (free acid) trifluoroacetate salt |
|---|---|---|---|---|
| CAS号 | 35263-73-1 | 分子量 | 1183.27 | |
| 密度 | 1.54 g/cm3 | 沸点 | N/A | |
| 分子式 | C55H74N16O14 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS08 |
信号词 | Danger |
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Direct regulation of gonadotrophin-releasing hormone (GnRH) transcription by RF-amide-related peptide-3 and kisspeptin in a novel GnRH-secreting cell line, mHypoA-GnRH/GFP.
J. Neuroendocrinol. 26(12) , 888-97, (2014) RF-amide-related peptide-3 [RFRP-3; also often referred to as the mammalian orthologue of the avian gonadotrophin-inhibitory hormone (GnIH)] and kisspeptin have emerged as potent modulators of neuroendocrine function via direct regulation of the reproductive ... |
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Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation.
Mol. Cell. Endocrinol. 402 , 95-106, (2015) Transmembrane helix seven residues of G protein-coupled receptors (GPCRs) couple agonist binding to a conserved receptor activation mechanism. Amino-terminal residues of the GnRH peptide determine agonist activity. We investigated GnRH interactions with the H... |
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Live birth rates after combined adjuvant therapy in IVF-ICSI cycles: a matched case-control study.
Reprod. Biomed. Online 30(4) , 340-8, (2015) The effectiveness of combined co-treatment with aspirin, doxycycline, prednisolone, with or without oestradiol patches, was investigated on live birth (LBR) rates after fresh and frozen embryo transfers (FET) in IVF and intracytoplasmic sperm injection cycles... |
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Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle.
J. Neurophysiol. 114 , 1008-21, (2015) Gonadotropin-releasing hormone (GnRH) controls mammalian reproduction via the hypothalamic-pituitary-gonadal (hpg) axis, acting on gonadotrope cells in the pituitary gland that express the GnRH receptor (GnRHR). Cells expressing the GnRHR have also been ident... |
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Effects of GnRH immunization on the reproductive axis and thymulin.
J. Endocrinol. 226 , 93-102, (2015) The bidirectional regulation of thymulin in the reproductive-endocrine function of the hypothalamic-pituitary-gonadal (HPG) axis of rats immunized against GnRH remains largely unclear. We explored the alterations in hormones in the HPG axis in immunized rats ... |
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The cryoprotective effect of Ficoll on the rabbit spermatozoa quality.
Zygote 23 , 785-94, (2015) The aim of this study was to evaluate the effect of the addition of Ficoll 70 into the cryopreservation medium containing sucrose and dimethyl sulfoxide (DMSO) on rabbit spermatozoa characteristics following freezing/thawing. This large molecular weight polym... |
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Neonatal outcomes after the implantation of human embryos vitrified using a closed-system device.
J. Assist. Reprod. Genet. 32(4) , 521-6, (2015) Closed vitrification poses a risk of adversely affecting embryo development, while it may minimize the risk of contamination. We assessed the effects of closed-system human embryo vitrification on fetal development after implantation, neonatal outcome, and cl... |
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Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration.
Mol. Endocrinol. 29(2) , 200-12, (2015) Hypogonadatropic hypogonadism (HH) can be acquired through energy restriction or may be inherited as congenital hypogonadotropic hypogonadism and its anosmia-associated form, Kallmann's syndrome. Congenital hypogonadotropic hypogonadism is associated with mut... |
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Identification of the link between the hypothalamo-pituitary axis and the testicular orphan nuclear receptor NR0B2 in adult male mice.
Endocrinology 156(2) , 660-9, (2015) The small heterodimer partner (SHP, nuclear receptor subfamily 0, group B, member 2; NR0B2) is an atypical nuclear receptor known mainly for its role in bile acid homeostasis in the enterohepatic tract. We previously showed that NR0B2 controls testicular func... |
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Transforming growth factor-β1 up-regulates connexin43 expression in human granulosa cells.
Hum. Reprod. 30 , 2190-201, (2015) Does transforming growth factor-β1 (TGF-β1) up-regulate connexin43 (Cx43) to promote cell-cell communication in human granulosa cells?TGF-β1 up-regulates Cx43 and increases gap junction intercellular communication activities (GJIC) in human granulosa cells, a... |