8-氨基喹啉
8-氨基喹啉结构式
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常用名 | 8-氨基喹啉 | 英文名 | 8-Aminoquinoline |
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| CAS号 | 578-66-5 | 分子量 | 144.17 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 289.8±0.0 °C at 760 mmHg | |
| 分子式 | C9H8N2 | 熔点 | 62-65ºC | |
| MSDS | 中文版 美版 | 闪点 | 171.5±8.1 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine.
Malaria Journal 11 , 259, (2012) The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only approved drug effective against the persistent liver stage of the hypnozoite forming strains Plasmodium vivax and Plasmodium ovale as well as Stage V gametocytes of Plasmodium falciparum. T... |
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Aminoquinolines as fluorescent labels for hydrophilic interaction liquid chromatography of oligosaccharides.
Biol. Chem. 393(8) , 757-65, (2012) In this study, we investigated the potential of four different aminoquinoline (AQ) compounds as fluorescent labels for glycan analysis using hydrophilic interaction liquid chromatography (HILIC) and fluorescence detection (FLD). We confirmed the optimal excit... |
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Copper chelator induced efficient episodic memory recovery in a non-transgenic Alzheimer's mouse model.
PLoS ONE 7(8) , e43105, (2012) Alzheimer's disease (AD) is a neurodegenerative syndrom involving many different biological parameters, including the accumulation of copper metal ions in Aβ amyloid peptides due to a perturbation of copper circulation and homeostasis within the brain. Copper... |
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Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity.
Proc. Natl. Acad. Sci. U. S. A. 110(43) , 17486-91, (2013) Individuals with glucose 6-phosphate dehydrogenase (G6PD) deficiency are at risk for the development of hemolytic anemia when given 8-aminoquinolines (8-AQs), an important class of antimalarial/antiinfective therapeutics. However, there is no suitable animal ... |
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Leishmaniasis: current status of available drugs and new potential drug targets.
Asian Pac. J. Trop. Med. 5(6) , 485-97, (2012) The control of Leishmania infection relies primarily on chemotherapy till date. Resistance to pentavalent antimonials, which have been the recommended drugs to treat cutaneous and visceral leishmaniasis, is now widespread in Indian subcontinents. New drug for... |
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An in vivo drug screening model using glucose-6-phosphate dehydrogenase deficient mice to predict the hemolytic toxicity of 8-aminoquinolines.
Am. J. Trop. Med. Hyg. 88(6) , 1138-45, (2013) Anti-malarial 8-aminoquinolines drugs cause acute hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDD). Efforts to develop non-hemolytic 8-aminoquinolines have been severely limited caused by the lack of a predictive in vi... |
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A quinoline based bis-urea receptor for anions: a selective receptor for hydrogen sulfate.
Nat. Prod. Commun. 7(3) , 301-4, (2012) A dipodal bis-urea receptor has been synthesized from the reaction of 8-amino quinoline and 1,4-phenylene diisocyanate in dichloromethane, and the anion binding ability of the receptor has been studied using fluoride, chloride, bromide, iodide, perchlorate, n... |
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Review: Improving the therapeutic index of 8-aminoquinolines by the use of drug combinations: review of the literature and proposal for future investigations.
Am. J. Trop. Med. Hyg. 85(6) , 1010-4, (2011) Because 8-aminoquinolines affect critical survival stages of Plasmodium parasites, treatment and control of malaria could be markedly improved by more widespread use of these drugs; however, hemolytic toxicity, which is widely prevalent in G6PD-deficient pati... |
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Cytotoxic palladium(II) complexes of 8-aminoquinoline derivatives and the interaction with human serum albumin
J. Inorg. Biochem. 106(1) , 46-51, (2012) Palladium(II) complexes are potential antitumor metallodrugs for their chemical resemblance to platinum(II) complexes. Two palladium(II) complexes ( 1 and 2) in the formula of [Pd L nCl] [ L 1 = N-( tert-butoxycarbonyl)- l-methionine- N′-8-quinolylamide, L 2 ... |
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Optical turn-on sensor based on graphene oxide for selective detection of D-glucosamine.
Anal. Chem. 84(13) , 5641-4, (2012) By incorporating the well-known fluorophore 8-aminoquinoline into graphene oxide, we have successfully prepared a turn-on fluorescent sensor capable of specific detection of D-glucosamine with a high selectivity and sensitivity. This methodology provides a ne... |