米法莫肽
米法莫肽结构式
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常用名 | 米法莫肽 | 英文名 | Mifamurtide |
|---|---|---|---|---|
| CAS号 | 83461-56-7 | 分子量 | 1237.499 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C59H109N6O19P | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Muramyl tripeptide (mifamurtide) for the treatment of osteosarcoma.
Expert Rev. Anticancer Ther. 9(8) , 1035-49, (2009) Osteosarcoma is an ultraorphan disease. There are approximately 1000 new patients diagnosed with osteosarcoma each year in the USA and Europe. Current treatment for osteosarcoma utilizes multiagent chemotherapy and surgical resection of all clinically detecta... |
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Imunomodulative effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) on mice with alveolar echinococcosis and treated with albendazole.
Parasitol. Res. 103(4) , 919-29, (2008) The effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) administered separately or with anthelmintic albendazole (ABZ) on cellular immunity of mice with alveolar echinococcosis was studied. The proliferative activity of splenic T and B... |
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In vitro and in vivo enhancement of canine pulmonary alveolar macrophage cytotoxic activity against canine osteosarcoma cells.
Cancer Biother. Radiopharm. 14(2) , 121-8, (1999) The combination of chemotherapy with immunotherapy may offer an advantage over either therapy alone and provide a greater potential for total tumor eradication. Monocyte/macrophage-mediated tumor cell killing is a major mechanism of the host's defense against... |
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Liposomal muramyl tripeptide (CGP 19835A lipid) therapy for resectable melanoma in patients who were at high risk for relapse: an update.
Cancer Biother. Radiopharm. 13(5) , 363-8, (1998) Liposome-encapsulated muramyl tripeptide-phosphatidyl ethanolamine (L-MTP-PE) was used in a pilot study for resectable melanoma patients who were at high risk for relapse. We entered 18 evaluable patients. The patient group included: (a) patients with stage I... |
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Effect of MTP on TNF-alpha in perfused rat liver after bacteremia and ischemia/reperfusion.
J. Surg. Res. 76(2) , 179-84, (1998) Muramlytripeptide phosphatidylethanolamine (MTP) stimulates synthesis of cytokines by hepatic Kupffer cells. We have shown in a perfused rat liver model that secondary ischemia/reperfusion (I/R) downregulates tumor necrosis factor alpha (TNF-alpha) expression... |
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Liposomal muramyl tripeptide phosphatidyl ethanolamine: a safe and effective agent against osteosarcoma pulmonary metastases.
Expert Rev. Anticancer Ther. 8(2) , 151-9, (2008) Osteosarcoma is the most common form of primary malignant bone tumor. The use of chemotherapy drugs with many side effects, including high-dose methotrexate, doxorubicin, cisplatin and ifosfamide, has greatly improved osteosarcoma survival compared with surge... |
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Mifamurtide in osteosarcoma--a practical review.
Drugs Today (Barc) 46(5) , 327-37, (2010) Mifamurtide, also known as liposomal muramyl tripeptide phosphatidyl ethanolamine (L-MTP-PE), has been approved for the treatment of osteosarcoma in Europe. Mifamurtide's rational drug design employs MTP-PE for macrophage activation in a multilamellar liposom... |
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Biologic response modifiers in pediatric cancer.
Hematol. Oncol. Clin. North Am. 15(4) , 723-40, ix, (2001) Biologic response modifiers are becoming an important addition to surgery, chemotherapy, and radiotherapy in the management of cancer. As this field of research grows and expands, more biologic response modifiers will be incorporated into therapeutic regimens... |
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Effect of liposomal muramyl tripeptide phosphatidylethanolamine and indomethacin on hematopoietic recovery in irradiated mice.
Physiol. Res. 51(5) , 511-21, (2002) The effects of liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE/MLV, radioprotective immunomodulator; 10 mg/kg) and indomethacin (INDO, inhibitor of prostaglandin production; 2 mg/kg) on post-irradiation recovery of hematopoietic functions in mic... |
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Administration of liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE) and diclofenac in the combination attenuates their anti-tumor activities.
Neoplasma 50(3) , 176-84, (2003) The anti-tumor effects of i.p. administered cyclooxygenase inhibitor - diclofenac and i.v. administered liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE) were investigated using a s.c. growing murine fibrosarcoma tumor. Tumor growth was assessed ... |