1-[4-(4-氟苯基)-4-氧亚基丁基]-[1,4-联哌啶]-4-甲酰胺二盐酸
![1-[4-(4-氟苯基)-4-氧亚基丁基]-[1,4-联哌啶]-4-甲酰胺二盐酸结构式](https://image.chemsrc.com/caspic/302/2448-68-2.png)
1-[4-(4-氟苯基)-4-氧亚基丁基]-[1,4-联哌啶]-4-甲酰胺二盐酸结构式
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常用名 | 1-[4-(4-氟苯基)-4-氧亚基丁基]-[1,4-联哌啶]-4-甲酰胺二盐酸 | 英文名 | Pipamperone Dihydrochloride |
|---|---|---|---|---|
| CAS号 | 2448-68-2 | 分子量 | 448.40 | |
| 密度 | N/A | 沸点 | 563.7ºC at 760 mmHg | |
| 分子式 | C21H32Cl2FN3O2 | 熔点 | 203-218ºC | |
| MSDS | 中文版 美版 | 闪点 | 294.7ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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The use of dried blood spots for quantification of 15 antipsychotics and 7 metabolites with ultra-high performance liquid chromatography - tandem mass spectrometry.
Drug Test. Anal. 7 , 502-11, (2015) Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alternative techniques, like dried blood spots (DBS), has conse... |
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Determination of Common Antipsychotics in Quantisal-Collected Oral Fluid by UHPLC-MS/MS: Method Validation and Applicability for Therapeutic Drug Monitoring.
Ther. Drug Monit. 38 , 87-97, (2016) Oral fluid (OF) is an interesting alternative for conventional blood testing in therapeutic drug monitoring. OF can be used for screening but its value for quantification has to be established.To evaluate the value of OF for quantification of 11 commonly used... |
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German insurer finds a third of people over 65 take five or more drugs a day.
BMJ 346 , f3905, (2013)
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Phelan-McDermid syndrome: clinical report of a 70-year-old woman.
Am. J. Med. Genet. A 161A(1) , 158-61, (2013) Phelan-McDermid or 22q13.3 deletion syndrome is characterized by global intellectual disability, childhood hypotonia, severely delayed or absent speech, features of autism spectrum disorder, without any major dysmorphisms or somatic anomalies. It is typically... |
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Evaluation of serotonin-2A receptor occupancy with 123I-5-I-R91150 and single-photon emission tomography before and after low-dose pipamperone administration in the canine brain.
Nucl. Med. Commun. 29(8) , 724-9, (2008) To conduct a cost-efficient pilot study on the effect of low-dose pipamperone on the serotonin-2A receptor binding in a large animal model with conventional single-photon emission tomography modalities.Three healthy drug-naive female Beagle dogs were scanned ... |
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Identification of selected psychopharmaceuticals and their metabolites in hair by LC/ESI-CID/MS and LC/MS/MS.
Forensic Sci. Int. 113(1-3) , 415-21, (2000) Hair samples of patients of psychiatry and hair samples of suicide cases were analysed by liquid-chromatography/ionspray-mass spectrometry (LC/MS) for antidepressants and neuroleptics. Electrospray ionisation (ESI) with in-source collision induced dissociatio... |
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Management of a severe forceful breather with Rett syndrome using carbogen.
Brain Dev. 28(10) , 625-32, (2006) We have used a novel neurophysiological technique in the NeuroScope system in combination with conventional electroencephalography (EEG) to monitor both brainstem and cortical activity simultaneously in real-time in a girl with Rett syndrome. The presenting c... |
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Determination of pipamperone in human plasma by high performance liquid chromatography.
Arzneimittelforschung 42(9) , 1069-72, (1992) A sensitive and reproducible high performance liquid chromatographic method was developed for the determination of pipamperone (1'-[4-(4-fluorophenyl)-4-oxobutyl]-[1,4'-bipiperidine]-4'- carboxamide, Dipiperon, CAS 1893-33-0) in plasma samples. Pipamperone an... |
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Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome.
Brain Res. 890(1) , 23-31, (2001) The serotonin (5-HT) syndrome is the most serious side effect of antidepressants, and it often necessitates pharmacotherapy. In the present study, the efficacy of several drugs was evaluated in an animal model of the 5-HT syndrome. When 2 mg/kg of clorgyline,... |
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Hypothermia induced by atypical neuroleptics.
Clin. Neuropharmacol. 21(6) , 344-6, (1998) Hypothermia is a potentially life-threatening emergency. This article examines the case of a 34-year-old, mentally retarded man who experienced three episodes of hypothermia during recurrent exposure to pipamperone. After the pipamperone dose was largely redu... |